摘要
目的探讨低分子肝素钙、依达拉奉联合高压氧治疗重度一氧化碳(CO)中毒的效果。方法选取2021年1月至12月宜春市人民医院收治的60例重度CO中毒患者作为研究对象,采用随机数字表法分为对照组和观察组,每组30例。两组患者入院后均给予高压氧、促醒等常规对症治疗,对照组在此基础上加用依达拉奉,观察组联合低分子肝素钙治疗。比较两组患者的临床疗效、意识恢复时间、清醒时间、迟发性脑病发生率以及血液流变学指标变化情况。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组患者的意识恢复时间、清醒时间均短于对照组,随访3个月迟发性脑病发生率低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后的血浆黏度、全血高切黏度、全血低切黏度、红细胞比容、红细胞变形指数、红细胞聚集指数均低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素钙、依达拉奉联合高压氧治疗重度CO中毒疗效显著,可明显改善患者血液流变学指标,且清醒时间短,迟发性脑病发生率低。
Objective To study the effect of Low Molecular Weight Heparin Calcium and Edaravone combined with hyperbaric oxygen on severe carbon monoxide(CO)poisoning.Methods A total of 60 patients with severe CO poisoning admitted to Yichun People′s Hospital from January to December 2021 were selected as the research objects and divided into control group and observation group by random number table method,with 30 cases in each group.After admission,patients in both groups were given routine symptomatic treatment such as hyperbaric oxygen and wake-up promotion.The control group was treated with Edaravone on this basis,and the observation group was treated with Low Molecular Weight Heparin Calcium.The clinical efficacy,consciousness recovery time,awake time,incidence of late-onset encephalopathy and changes of hemorheology were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The consciousness recovery time and awake time of the patients in the observation group were shorter than those in the control group,and the incidence of delayed encephalopathy was lower than that in the control group after 3 months of follow-up,and the differences were statistically significant(P<0.05).The plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,hematocrit,erythrocyte deformation index and erythrocyte aggregation index in the observation group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Low Molecular Weight Heparin Calcium and Edaravone combined with hyperbaric oxygen can significantly improve the hemorheological indexes of patients with severe CO poisoning,with short awake time and low incidence of delayed encephalopathy.
作者
蔡双
CAI Shuang(Department of Emergency Medicine,Yichun People′s Hospital,Jiangxi Province,Yichun336000,China)
出处
《中国当代医药》
CAS
2022年第29期58-60,64,共4页
China Modern Medicine
基金
江西省宜春市科技计划项目(JXYC2021KSA026)。
关键词
重度一氧化碳中毒
低分子肝素钙
依达拉奉
高压氧
迟发性脑病
Severe carbon monoxide poisoning
Low Molecular Weight Heparin Calcium
Edaravone
Hyperbaric oxygen
Delayed encephalopathy
