摘要
目的探讨奥拉西坦、胞磷胆碱联合神经节苷脂注射液治疗一氧化碳中毒的效果及对心肌损伤标志物、神经功能的影响。方法选取2017年10月至2020年10月收治的90例一氧化碳中毒患者,根据随机数字表法将其分为对照组与观察组,各45例。对照组采用奥拉西坦+胞磷胆碱治疗,观察组在对照组基础上给予神经节苷脂注射液治疗。比较两组的临床效果。结果观察组的治疗总有效率为97.78%,高于对照组的86.67%(P<0.05)。治疗后,观察组的pro-BNP、CK-MB及cTnI水平均低于对照组(P<0.05)。治疗后,观察组的NIHSS评分低于对照组,MMSE评分高于对照组(P<0.05)。结论奥拉西坦、胞磷胆碱联合神经节苷脂注射液治疗一氧化碳中毒的效果显著,可减轻患者心肌损伤,促进患者神经功能改善,值得临床推广应用。
Objective To explore the effect of oxiracetam,citicoline combined with ganglioside injection in the treatment of carbon monoxide poisoning and its influence on myocardial injury markers and nerve function.Methods A total of 90 patients with carbon monoxide poisoning treated from October 2017 to October 2020 were selected and divided into control group and observation group according to random number table method,with 45 cases in each group.The control group was treated with oxiracetam+citicoline,and the observation group was treated with ganglioside injection on the basis of the control group.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 97.78%,which was higher than 86.67%in the control group(P<0.05).After treatment,the levels of pro-BNP,CK-MB and cTnI in the observation group were lower than those in the control group(P<0.05).After treatment,the NIHSS score in the observation group was lower than that in the control group,and the MMSE score was higher than that in the control group(P<0.05).Conclusion Oxiracetam,citicoline combined with ganglioside injection in the treatment of carbon monoxide poisoning has a significant effect,it can reduce myocardial injury and promote the improvement of nerve function of patients,which is worthy of clinical promotion and application.
作者
张攀
杨成
ZHANG Pan;YANG Cheng(Shaanxi Sengong Hospital,Xi'an 710300,China)
出处
《临床医学研究与实践》
2021年第32期69-71,共3页
Clinical Research and Practice
