摘要
目的:调查辅助生殖门诊女性不孕症发生情况并分析危险因素.方法:采用回顾性方法,收集2019年1月-2021年12月在本院辅助生殖门诊就诊的女性不孕症患者1016例临床资料(病例组),按照1:1的比例且年龄差异≤2年、同居未避孕1年内自然妊娠的女性1016例为对照组.多因素logistic回归分析女性不孕症相关影响因素.结果:病例组中原发性不孕254例(25.0%)、继发性不孕762例(75.0%).病例组与对照组年龄、文化程度、流产/引产史、异位妊娠史、全身疾病史无差异(P>0.05),结婚年龄、月经初潮年龄、初次性生活年龄、性生活频率、月经史、产后/流产后并发症史、泌尿生殖系感染史、肥胖占比等均有差异(P<0.05).多因素分析显示,性生活频率>8次/月(OR=1.506,95%CI1.067~2.337)、月经不规律(OR=1.412,95%CI1.152~2.196)、有产后/流产后并发症史(OR=3.585,95%CI1.682~6.824)、有泌尿生殖系感染史(OR=4.898,95%CI3.153~13.296)、肥胖(OR=2.065,95%CI 1.625~6.824)均是女性不孕症的危险因素,月经初潮年龄<13岁(OR=0.814,95%CI0.599~0.924)、初次性生活年龄≤20岁(OR=0.892,95%CI0.718~0.987)是女性不孕症的保护因素(均P<0.05).结论:初潮年龄早、性生活过早、泌尿生殖系统感染史、肥胖等是女性不孕症的独立危险因素,提示当地应加强生殖健康教育,减少不孕症危险因素,降低不孕症发生风险.
Objective: To investigate the situation of infertility of women from assisted reproductive clinics, and to analyze the risk factors of their infertility. Methods: Retrospective method was used to collect the clinical data of 1016 infertility women(case group) in the assisted reproduction clinic of Tangshan maternal and child health care hospital. According to the ratio of 1:1, the women with natural pregnancy and without contraception used within 1 year were selected in control group. Multivariate logistic regression analysis was used to analyze the related factors affecting female infertility. Results: There were 254(25.0%) women with primary infertility and 762(75.0%) women with secondary infertility in the case group. There were no significant differences in age, educational level, history of abortion/induced labor, history of ectopic pregnancy, and history of systemic diseases of the women between the two groups(P>0.05). The age of marriage, the menarche age, the age and frequency of the first sexual intercourse, the menstrual history, the history of postpartum and post-abortion complications, the history of genitourinary infection, and the proportion of obesity of the women between the two groups(P>0.05). Multivariate analysis showed that sexual frequency >8 times/month(OR=1.506, 95%CI: 1.067-2.337), the irregular menstruation(OR=1.412, 95%CI: 1.152-2.196), and the history of postpartum and post-abortion complications(OR=3.585, 95%CI: 1.682-6.824), the history of urogenital infection(OR=4.898, 95%CI: 3.153-13.296), the obesity(OR=2.065, 95%CI: 1.625-6.824) were all the risk factors of female infertility.The menarche<13years old(OR=0.814,95%CI:0.599-0.924)and the age of the first sexual intercourse≤20years old(OR=0.892,95%CI:0.718-0.987)were the protective factors of female infertility(all P<0.05).Conclusion:Early menarche age,early sexual life,history of urogenital infection,obesity,and so on of the women are the independent risk factors of their infertility,which suggest that local reproductive health edu
作者
许晓东
李翠
刘静
于倩
易建平
XU Xiaodong;LI Cui;LIU Jing;YU Qian;YI Jianping(Tangshan Maternal and Child Health Care Hospital,Tangshan,Hebei Province,063000)
出处
《中国计划生育学杂志》
2022年第10期2316-2320,共5页
Chinese Journal of Family Planning
基金
河北省卫生健康委科研基金项目(20201475)。
