摘要
目的 探讨5-氨基酮戊酸光动力疗法(PDT)治疗外阴硬化性苔藓的临床疗效。方法 选取自2019年1月至2020年12月北部战区总医院妇科门诊就诊的60例外阴硬化性苔藓患者为研究对象。根据随机数字表法将患者分为糠酸莫米松组和PDT组,每组各30例。糠酸莫米松组患者给予糠酸莫米松乳膏外用治疗,PDT组患者给予5-氨基酮戊酸PDT,比较两组患者的临床疗效以及不良反应发生情况等。结果 治疗前,两组患者的临床症状体征评分比较,差异无统计学意义(P>0.05)。治疗后,PDT组患者病损范围、瘙痒程度、皮肤弹性、皮肤颜色等各项临床症状体征评分均低于糠酸莫米松组,差异有统计学意义(P<0.05)。PDT组患者的临床总有效率为96.7%(29/30),明显高于糠酸莫米松组的76.7%(23/30),差异有统计学意义(P<0.05)。PDT组患者出现疼痛、红肿、过敏及炎症反应等不良发应的发生率为23.3%(7/30),明显低于糠酸莫米松组的50.0%(15/30),差异有统计学意义(P<0.05)。结论 5-氨基酮戊酸PDT治疗妇女外阴硬化性苔藓疗效较佳,安生性较好。
Objective To investigate the clinical efficacy of 5-aminolevulinic acid photodynamic therapy(PDT) in the treatment of vulvar lichen sclerosus.Method A retrospective study was performed on 60 patients with lichen sclerosus vulva from January 2019to December 2020.According to the random number table method, the patients were divided into mometasone furoate group and PDT group, 30 cases in each group.The patients in Mometasone furoate group were given topical mometasone furoate cream treatment, and the patients in PDT group were given 5-aminolevulinic acid PDT. The clinical efficacy and the occurrence of adverse reactions were compared between the two groups.Results Before treatment, there was no significant difference in the scores of clinical symptoms and signs between the two groups(P >0.05). After treatment, the scores of clinical symptoms and signs such as lesion range, itching degree, skin elasticity, and skin color in the PDT group were lower than those in the mometasone furoate group, and the difference was statistically significant(P<0.05). The total clinical effective rate in the PDT group was 96.7%(29/30), which was significantly higher than 76.7%(23/30) of Mometasone furoate group, with a statistically significant difference(P<0.05).The incidence of adverse reactions such as pain, redness, swelling, allergy and inflammation in PDT group was 23.3%(7/30), which was significantly lower than that in mometasone furoate group 50.0%(15/30), and the difference was statistically significant(P<0.05). Conclusions 5-aminolevulinic acid PDT in the treatment of women with vulvar lichen sclerosus has better efficacy and safety.
作者
张晓梅
陈静
ZHANG Xiao-mei;CHEN Jing(Department of Obstetrics and Gynecology,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《创伤与急危重病医学》
2022年第5期344-347,共4页
Trauma and Critical Care Medicine
基金
省博士科研启动基金计划项目(2020-BS-034)。
