摘要
目的探究甘油三酯-葡萄糖指数(trigiuceride-glucose index,TyG)与轻型缺血性卒中(mild ischemic stroke,MIS)患者早期神经功能恶化(early neurological deterioration,END)的相关性。方法本研究为回顾性研究。连续纳入2019年1月至2020年12月保定市第一中心医院神经内科收治的首次发病且发病在72h内的急性MIS患者。记录患者入院时美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分,于次日清晨抽取空腹静脉血,测定血常规、肝功能、肾功能、血脂等相关血液指标,计算出TyG指数ln[TG(mg/dl)×FBG(mg/dl)]/2。并根据患者神经功能恶化情况将其分为END组和非END组,采用多因素logistic回归分析急性MIS患者发生END的相关影响因素,并采用受试者工作特征曲线(ROC)评价TyG指数对急性MIS患者END的预测作用。结果最终纳入急性MIS患者149例,其中END组39例,非END组110例,多因素Logistic回归分析显示,中性细胞比率(OR 1.054,95%CI 1.009~1.101,P=0.017)、TBIL(OR 0.718,95%CI 0.611~0.845,P<0.001)、TyG指数(OR 5.072,95%CI 1.645~15.640,P=0.005)是急性MIS患者发生END的独立危险因素;ROC曲线分析显示,TyG指数对END的诊断界值为1.74,敏感度为53.8%,特异度为81.8%。结论TyG指数升高是急性MIS患者发生END的危险因素之一,对急性MIS患者END的发生具有一定预测作用。
Objective To investigate the correlation between the trigiuceride-glucose index and early neurological deterioration(END)in patients with mild ischemic stroke(MIS).Methods This study was retrospective.Patients with acute MIS who were admitted to the Department of Neurology of the First Central Hospital of Baoding from January 2019 to December 2020 for the first time and within 72 h of onset were consecutively included.The National Institute of Health Stroke Scale(NIHSS)scores were recorded at the time of admission,and fasting venous blood was drawn in the early morning of the following day to determine routine blood,liver function,renal function,lipids and other relevant blood indices,and the trigiuceride-glucose index was calculated ln[TG(mg/dl)×FBG(mg/dl)]/2.The patients were divided into END and non-END groups according to their neurological deterioration.Multi-factor logistic regression was used to analyze the factors associated with the occurrence of END in acute MIS patients,and the subject operating characteristic curve(ROC)was used to evaluate the predictive effect of the trigiuceride-glucose index on END in acute MIS patients.Results A final total of 149 patients with acute MIS were included,39 in the END group and 110 in the non-END group.Multi-factor logistic regression analysis showed that neutrophil ratio(OR 1.054,95%CI 1.009~1.101,P=0.017)、TBIL(OR 0.718,95%CI 0.611~0.845,P<0.001)and trigiuceride-glucose index(OR 5.072,95%CI 1.645~15.640,P=0.005)were independent risk factors for the development of END in patients with acute MIS.The ROC curve analysis showed that the diagnostic cut-off value of trigiuceride-glucose index for END was 1.74 with a sensitivity of 53.8%and specificity of 81.8%.Conclusion Elevated trigiuceride-glucose index is one of the risk factors for the development of END in patients with acute MIS and has a predictive role for the development of END in patients with acute MIS.
作者
王梦
卢丹丹
祖赛
李蒙蒙
王佩
刘晨曦
冯锐
魏书艳
WANG Meng;LU Dandan;ZU Sai(Graduate School of Chengde Medical College,Chengde 067000,China)
出处
《中风与神经疾病杂志》
CAS
2022年第9期808-812,共5页
Journal of Apoplexy and Nervous Diseases
基金
保定市科技支撑计划(No.2041ZF246)。
关键词
轻型缺血性卒中
早期神经功能恶化
TyG指数
Mild ischemic stroke
Early neurological deterioration
Trigiuceride-glucose index
