摘要
海洋是近年来极具潜力的抗肿瘤新药开发和筛选的重要来源,每年约有56%的海洋生物活性化合物被发现具有抗肿瘤作用。本文对已发现的在抗肿瘤方面具有治疗作用的海洋来源药物进行了分类归纳,以肿瘤免疫治疗为主要方向,首先对免疫系统在癌症发病中的作用简短回顾并探讨了肿瘤免疫治疗当前的困境,同时总结了海洋药物在其中的主要特点及作用机制。进一步地,对目前已批准药物以物种来源进行了分组、归纳并概述了其被发现的历史、药物的结构特征、相关的作用通路、临床应用及治疗的特点。最后,总结了目前海洋药物研究的不足,展望了新药开发的未来前景及趋势。
In recent years,the oceans have provided an important source of highly promising new anti-tumor drugs for innovation and screening,with approximately 56%of biologically active compounds being discovered to have anti-tumor effects each year.In this study,we classified and summarized the approved drugs of marine origin in terms of anti-tumor therapy,and firstly,we briefly overviewed the role of the immune system in cancer pathogenesis and discussed the current dilemma of cancer immunotherapy and highlighted the main anti-tumor targets of marine drugs.Further,with a focus on tumor immunity,we classified and outlined the history of currently approved marine original drugs by species origin,structural features,relevant pathways,and clinical application and therapy.Lastly,the limitations of current marine drug research were discussed,as well as prospects and trends in new drug development.
作者
欧阳紫君
孙晓凡
孙海燕
孙洋
OUYANG Zi-jun;SUN Xiao-fan;SUN Hai-yan;SUN Yang(Institute of Marine Biomedicine,School of Food and Drug,Shenzhen Polytechnic,Shenzhen 518055,China;State Key Laboratory of Pharmaceutical Biotechnology,Department of Biotechnology and Pharmaceutical Sciences,School of Life Sciences,Nanjing University,Nanjing 210023,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第9期2642-2653,共12页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81872877)
广东省普通高校特色创新类项目(2019GKTSCX039,2020KTSCX295)
深圳职业技术学院校级科研项目(6021310023K).
关键词
海洋来源药物
抗肿瘤药物
肿瘤免疫
天然产物
信号通路
drug of marine origin
anti-tumor drug
tumor immunity
natural product
signaling pathway
