摘要
目的:分析益骨汤治疗老年膝骨关节炎的临床价值。方法:选择2020年1月-2022年1月安吉县中医医院治疗的80例老年膝骨关节炎患者作为研究对象,随机分为试验组(40例)和对照组(40例)。对照组口服塞来昔布胶囊,试验组采用益骨汤治疗。对比两组临床疗效、骨代谢指标、炎症因子水平、骨关节功能、中医症候积分及不良反应情况。结果:试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组骨保护素(osteoprotegerin,OPG)、胰岛素样生长因子1(insulin like growth factor-1,IGF-1)及骨钙素(bone gla protein,BGP)水平、核因子κB受体活化因子配基(RANKL)比较差异无统计学意义(P>0.05);治疗后4周,两组OPG、IGF-1、BGP均高于治疗前,RANKL低于治疗前,且试验组OPG、IGF-1、BGP更高,RANKL更低,差异有统计学意义(P<0.05)。治疗前,两组TNF-α、IL-1β、IL-6比较差异无统计学意义(P>0.05);治疗后8周,两组TNF-α、IL-1β、IL-6较治疗前降低,且试验组TNF-α、IL-1β、IL-6水平更低,差异有统计学意义(P<0.05)。治疗前,两组的WOMAC、中医症候积分比较差异无统计学意义(P>0.05);治疗后2、4、8周,两组WOMAC、中医症候积分较之前降低,且试验组WOMAC、中医症候积分更低(P<0.05)。试验组不良反应率低于对照组,差异有统计学意义(P<0.05)。结论:益骨汤治疗膝骨关节炎能缓解临床症状,显著降低炎症因子水平,改善骨代谢,延缓疾病进程。
Objective:To analyze the clinical value of Yigu Decoction in the treatment of senile knee osteoarthritis.Method:A total of 80 elderly patients with knee osteoarthritis who were treated in Anji County Traditional Chinese Medicine Hospital from January 2020 to January 2022 were selected as the research subjects,and randomly divided into experimental group (40 cases) and control group (40 cases).The control group was given oral Celecoxib Capsules,and the experimental group was given Yigu Decoction.The clinical efficacy,bone metabolism indexes,inflammatory factor levels,bone and joint function,TCM symptom scores and adverse reactions were compared between the two groups.Result:The total effective rate in the experimental group was higher than that in the control group,and the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in osteoprotegerin (OPG),insulin like growth factor-1 (IGF-1),bone gla protein (BGP),receptor activator of nuclear κB ligand (RANKL) between the two groups (P>0.05);at 4 weeks after treatment,OPG,IGF-1 and BGP were higher and RANKL was lower in the two groups than before treatment,and OPG,IGF-1 and BGP were higher and RANKL was lower in the experimental group,and the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in TNF-α,IL-1β and IL-6 between the two groups (P>0.05);at 8 weeks after treatment,the levels of TNF-α,IL-1β and IL-6 in the two groups were lower than those before treatment,and the levels of TNF-α,IL-1β and IL-6 in the experimental group were lower,and the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in the WOMAC and TCM symptom scores between the two groups (P>0.05);2,4,8 weeks after treatment,the WOMAC and TCM symptom scores in the two groups were lower than before,and WOMAC and TCM symptom scores of the experimental group were lower (P<0.05).The adverse reactions rate in the experimental group was lowe
作者
张隽
ZHANG Juan(Anji County Traditional Chinese Medicine Hospital,Anji 313300,China)
出处
《中外医学研究》
2022年第27期10-14,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
膝骨关节炎
炎症因子
骨代谢
Knee osteoarthritis
Inflammatory factors
Bone metabolism
