摘要
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期妇女最常见的一种复杂的异质性内分泌代谢疾病,其临床表现多样,涉及全身多器官、多系统,是导致不孕及代谢紊乱的原因之一。PCOS关乎女性一生的健康,在其病因学、诊断标准和最佳治疗方案上尚有许多争论和悬而未决的问题。目前认为遗传和环境因素共同导致了疾病的发生,表观遗传学将环境因素和遗传因素联系起来,代谢组学揭示了PCOS的病因、机制与潜在的治疗靶点,肠道菌群从微观角度解释了肠道微生物与宿主之间的相互串扰。本文通过阐述表观遗传学、代谢组学、肠道菌群三个方面探讨其在PCOS的研究进展,以期深入理解疾病发病机制,为临床治疗提供新方向。
Polycystic ovary syndrome(PCOS)is the most common and complex heterogeneous endocrine and metabolic disease,with diverse clinical manifestations involving multi-organ and multi-system,and being one of the causes of infertility and metabolic disorder in women at childbearing age. PCOS threatens the health of women throughout their lives.There have still been so many debates and unsolved issues about its etiology,diagnostic criteria,and optimal treatment. It is currently believed that the occurrence of PCOS is jointly caused by genetic and environmental factors. Epigenetics combines these two factors together. Metabolomics reveals the etiology,mechanisms,and potential therapeutic targets of PCOS. Gut microbiota explains the gut microbes and their hosts interfere mutually.This article aims to discuss the research progress of PCOS in the aspects of epigenetics,metabolomics and microbiota,hoping to better understandthe pathogenesis andtoprovide a new direction for clinical treatment.
作者
李荔
周嘉禾
李末娟
钟明琳
张小伟
许秋仪
梁莲云
LI Li;ZHOU Jiahe;LI Mojuan;ZHONG Minglin;ZHANG Xiaowei;XU Qiuyi;LIANG Li-anyun(Guangdong Women and Children′s Hospital,Guangzhou 511442,China)
出处
《实用医学杂志》
CAS
北大核心
2022年第16期1987-1992,共6页
The Journal of Practical Medicine
基金
2021年广东省自然科学基金(编号:2021A515010763)
2021年度澳门特别行政区科学技术发展基金(编号:0048/2021/A1)
广东省中医药局重点专项(编号:20184005)
广州市科技计划科学研究专项(编号:201904010458)。
