摘要
【目的】探究引火归元理论指导下灸法治疗对妇科肿瘤化疗患者癌因性疲乏和生活质量的影响。【方法】将74例妇科肿瘤(子宫内膜癌或卵巢癌)化疗后癌因性疲乏患者随机分为观察组和对照组,每组各37例。对照组采用常规护理,观察组在常规护理的基础上加用引火归元理论指导下的灸法治疗。每天治疗1次,每周治疗6 d,每个疗程3周,连续治疗3个疗程。观察2组患者化疗前后Piper疲乏修订量表(PFS-R)评分、中文版生命质量测定量表(EORTC QLQ-C30)评分及白细胞、血红蛋白水平的变化情况,并比较2组患者牙龈肿痛、口腔溃疡及咽喉痛的发生情况。【结果】(1)研究过程中,治疗组脱落3例,对照组无脱落病例。最终共有71例患者完成试验,其中,治疗组34例,对照组37例。(2)疲乏程度方面,2组患者的PFS-R量表评分在组间效应、时间效应、周期效应及交互效应方面差异均有统计学意义(P<0.001)。各疗程化疗后,2组患者PFS-R量表的疲乏总分及行为、情感、感知、认知等各维度评分均较化疗前升高(P<0.05),但观察组的升高幅度均明显低于对照组(P<0.05)。(3)生活质量方面,治疗后(第3次化疗后),观察组患者EORTC QLQ-C30量表的各功能领域、各症状领域、各单一条目和总体健康评分均较治疗前改善(P<0.05或P<0.01),而对照组仅角色功能和气促、疼痛症状较治疗前改善(P<0.05),其他各领域评分无改善(P>0.05)或恶化(P<0.05);组间比较,观察组对EORTC QLQ-C30量表各领域评分的改善作用均明显优于对照组(P<0.05或P<0.01)。(4)白细胞水平方面,观察组各疗程化疗后的白细胞水平均无明显降低(P>0.05),而对照组第2次、第3次化疗后的白细胞水平均较同一化疗周期的化疗前和第1化疗周期的化疗后明显降低(P<0.05);组间比较,观察组在第3次化疗后的白细胞水平明显高于对照组(P<0.05)。(5)血红蛋白水平方面,2组患者第1次、第
Objective To explore the effect on cancer-related fatigue(CRF)and quality of life(QOL)in the patients with gynecological cancer after chemotherapy treated by the moxibustion under the guidance of the theory of“conducting fire back to its source”.Methods Seventy-four patients with gynecological tumor(endometrial cancer or ovarian cancer)with cancer-related fatigue after chemotherapy were randomly divided into observation group and control group,with 37 cases in each group.The control group was treated with conventional nursing,and the observation group was treated with moxibustion therapy guided by the theory of“conducting fire back to its source”together with conventional nursing.The patients were treated once daily for 6 days a week,3 weeks constituted one course of treatment,and the treatment lasted for 3 consecutive courses.The changes in the scores of the revised Piper fatigue scale(PFS-R),the scores of Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30(EORTC QLQ-C30),and the levels of white blood cell(WBC)and hemoglobin in the two groups were observed before and after chemotherapy.Meanwhile,the incidence of gingival swelling and pain,oral ulcer and sore throat in the two groups were compared.Results(1)During the trial,there were 3 cases fell off in the treatment group and no cases fell off in the control group.A total of 71 patients completed the trial,including 34 cases in the treatment group and 37 cases in the control group.(2)In terms of fatigue degree,there were statistically significant differences in the PFS-R scale scores between the two groups in terms of group effect,time effect,and interaction effect(P<0.001).After each course of chemotherapy,the total fatigue scores and the scores of behavioral,emotional,perceptual,and cognitive dimensions of the PFS-R scale in both groups were increased compared with those before chemotherapy(P<0.05),but the increased range in the observation group was significantly lower than that in t
作者
宋嘉婷
黄绮华
文希
简乐乐
SONG Jia-Ting;HUANG Qi-Hua;WEN Xi;JIAN Le-Le(The Second Clinical Medical School of Guangzhou University of Chinese Medicine,Guangzhou 510120 Guangdong,China;Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2022年第9期2094-2101,共8页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医院院内课题专项(编号:YN2018HL06)。
关键词
引火归元
灸法
妇科肿瘤
子宫内膜癌
卵巢癌
化疗
癌因性疲乏
生活质量
虚火上浮
conducting fire back to its source
moxibustion
gynecological tumor
endometrial cancer
ovarian cancer
chemotherapy
cancer-related fatigue
quality of life
flaring-up of deficient fire
