摘要
骨关节炎(osteoarthritis, OA)是由衰老、肥胖、创伤、遗传等多因素引起的慢性退行性疾病,是临床上骨科医生面临的棘手疾病,该病给患者及其家庭带来了沉重的负担。白藜芦醇是一种具有抗炎、抗氧化等作用的天然化合物,可通过影响软骨衰老、软骨基质代谢、软骨损伤等作用参与OA的发生发展进程,这一过程可能与核因子-κB(NF-κB)、Toll样受体4(TLR4)、细胞外信号调节激酶(ERK)等信号通路的调控有关。本文拟就白藜芦醇在OA进程中的作用及其可能机制的研究进展作一综述,以期为相关研究提供参考。
Osteoarthritis(OA) is a chronic degenerative disease caused by aging, obesity, trauma, heredity and other factors, which is a difficult disease faced by orthopedic doctors in clinic, and brings a heavy burden to patients and families. Resveratrol is a natural compound with anti-inflammatory and antioxidant effects. It can affect cartilage aging, cartilage matrix metabolism, and cartilage injury in participate in the process of OA, which might be related to NF-κB, TLR4 and ERK signaling pathway. This paper reviews the research progress of resveratrol in the process of OA and its possible mechanism, so as to facilitate relevant research.
作者
褚云峰
于红燕
杨琪
彭艳斌
陈仲
刘明
于斐
CHU Yunfeng;YU Hongyan;YANG Qi;PENG Yanbin;CHEN Zhong;LIU Ming;YU Fei(Peking University Shenzhen Hospital,Shenzhen 518036,China;Bincheng District Municipal Hospital,Binzhou 256600,China;National&Local Joint Engineering Research Center of Orthopaedic Biomaterials,Shenzhen 518036,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2022年第9期1351-1355,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金(82102568,82102076,82172432,82001319)
广东省基础与应用基础研究基金(2021A1515012586,2019A1515110983,2019A1515011290)
白求恩·石药骨质疏松科研基金项目(G-X-2020-1107-21)
北京大学深圳医院科研启动金项目(KYQD2021099)。
关键词
骨关节炎
白藜芦醇
软骨退化
信号通路
机制研究
osteoarthritis
resveratrol
cartilage degeneration
signaling pathway
mechanism research
