摘要
骨关节炎(OA)是常见的退行性关节疾病,发病率逐年攀升,治疗常以镇痛类及非甾体抗炎药为主,长期使用易造成胃肠损伤,出现病情反复的现象。中药防治OA历史悠久,应用广泛、不良反应少,具有治疗范围广、多靶点、多途径等独特优势。中药有效成分通过干预氧化应激(OS)反应生物标志物丙二醛(MDA)和超氧化物歧化酶(SOD)表达,降低活性氧(ROS)含量,减轻OS损伤,增加机体的抗氧化能力,通过调控核因子E2相关因子2(Nrf2)/血红素氧合酶-1(HO-1)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)、核转录因子-κB(NF-κB)、c-Jun氨基末端激酶(JNK)、NOD样受体蛋白3(NLRP3)和骨保护素(OPG)等信号通路,下调白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)等炎症因子表达,有效缓解关节局部炎症反应,保护软骨细胞与骨组织,抑制软骨细胞凋亡,进一步缓解OA疾病发展进程。目前OA医学研究现状与发展趋势仍存在一定局限,需要继续发展中医药事业,该文对中药有效成分调控OS反应以防治OA的相关文献报道进行综述,为后续研究提供新的方向和思路。
Osteoarthritis(OA)is a common degenerative joint disease with a rising incidence rate year by year.Treatment often relies on analgesics and non-steroidal anti-inflammatory drugs(NSAIDs),which can lead to gastrointestinal damage with long-term use and the recurrence of symptoms.Chinese medicine has a long history of preventing and treating OA,with widespread application and fewer side effects.It offers unique advantages such as a broad treatment scope,multiple targets,and pathways.The effective components of Chinese medicine can reduce the content of reactive oxygen species(ROS),relieve oxidative stress(OS)damage,and increase the antioxidant capacity of the body by interfering with the expression of biomarkers of OS response such as malondialdehyde(MDA)and superoxide dismutase(SOD).Through the modulation of signaling pathways such as nuclear factor E_2-related factor 2(Nrf2)/heme oxygenase-1(HO-1),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),nuclear factor kappa B(NF-κB),c-Jun N-terminal kinase(JNK),NOD-like receptor protein 3(NLRP3),and osteoprotegerin(OPG),they downregulated the expression of inflammatory factors such as interleukin-6(IL-6),interleukin-1β(IL-1β),and tumor necrosis factor-α(TNF-α),thereby effectively relieving local joint inflammation,protecting chondrocytes and bone tissue,inhibiting chondrocyte apoptosis,and further alleviating the progression of OA.Currently,there are still certain limitations in the medical research status and development trends of OA,necessitating the continued advancement of traditional Chinese medicine.This paper reviewed the literature on the regulation of OS response by effective components of Chinese medicine for the prevention and treatment of OA,providing new directions and ideas for future research.
作者
张爽
毕映燕
刘晓婷
宫玉锁
刘学睿
元宝华
禄成龙
陈绪帆
王莹
光佳如
ZHANG Shuang;BI Yingyan;LIU Xiaoting;GONG Yusuo;LIU Xuerui;YUAN Baohua;LU Chenglong;CHEN Xufan;WANG Ying;GUANG Jiaru(Gansu Provincial Hospital of Traditional Chinese Medicine(TCM),Lanzhou 730000,China;Gansu University of Chinese Medicine,Lanzhou 730000,China;Ningxia Hui Autonomous Region Sports Science and Technology Center,Yinchuan 750001,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第11期282-289,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
甘肃省自然科学基金项目(23JRRA1239、22JR11RA197、23JRRA1237)
甘肃省重点人才项目和陇原青年创新创业人才(团队)项目(甘组通字[2022]77号)。
关键词
中药有效成分
氧化应激
抗氧化
骨关节炎
active ingredients of Chinese medicine
oxidative stress
anti-oxidation
osteoarthritis
