摘要
支气管肺发育不良(bronchopulmonary dysplasia,BPD)是早产儿的常见呼吸系统并发症,严重影响早产儿预后和生存质量。近年来,尽管新生儿救治水平取得了巨大进步,但BPD的发生率仍然居高不下。用于预防和治疗BPD的药物,如外源性肺表面活性物质、糖皮质激素、咖啡因等,经过不断的探索和应用,已广泛用于临床,而利尿剂、一氧化氮、支气管扩张剂等药物则缺乏足够的有效性及安全性证据。本文将通过文献检索、分类总结,对预防BPD的药物进行综述。
Bronchopulmonary dysplasia(BPD)is a common respiratory complication after preterm birth that severely affects the prognosis and quality of life in preterm infants.In recent years,significant progress has been made in neonatal care,but the incidence of BPD remains high.After long-term exploration and application,some medications such as exogenous pulmonary surfactants,glucocorticoids and caffeine have been widely used for the prevention and treatment of BPD.However,some medications including diuretics,inhaled nitric oxide and bronchodilators have not been proved to be effective and safe.This review summarizes the present drugs for the prevention of BPD in publications.
作者
卜星河
周建国
Bu Xinghe;Zhou Jianguo(Department of Neonatology,Children's Hospital of Fudan University,Shanghai 201102,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2022年第9期703-708,共6页
Chinese Journal of Perinatal Medicine
基金
国家自然科学基金(81801502)。
关键词
支气管肺发育不良
药物疗法
化学预防
婴儿
早产
Bronchopulmonary dysplasia
Drug therapy
Chemoprevention
Infant,premature
