摘要
目的探讨急性心肌梗死患者血清尿酸、转化生长因子β1(TGF-β1)、糖类抗原12-5(CA12-5)的表达水平及其联合预测新发房颤的价值。方法选取364例急性心肌梗死患者(观察组)与350例健康体检者(对照组),检测两组研究对象的血清尿酸、TGF-β1、CA12-5水平。根据观察组患者住院期间有无发生房颤将其分为发生组和未发生组,比较两组患者的血清尿酸、TGF-β1、CA12-5水平。采用Logistic回归模型分析急性心肌梗死患者新发房颤的危险因素。绘制受试者工作特征(ROC)曲线以分析血清尿酸、TGF-β1、CA12-5水平联合预测急性心肌梗死患者新发房颤的效能。结果观察组的血清尿酸、TGF-β1、CA12-5水平均高于对照组(均P<0.05)。观察组中有38例患者新发房颤,发生率为10.44%;相比于未发生组,发生组患者年龄≥65岁的比例、Killip分级≥Ⅱ级的比例,以及血清尿酸、TGF-β1、CA12-5水平均更高,而左心室射血分数更低(均P<0.05)。Logistic回归分析显示,年龄≥65岁、Killip分级≥Ⅱ级及高水平的血清尿酸、TGF-β1、CA12-5均是急性心肌梗死患者新发房颤的危险因素,左心室射血分数升高是其保护因素(均P<0.05)。ROC曲线分析结果显示,血清尿酸、TGF-β1、CA12-5联合预测急性心肌梗死患者新发房颤的灵敏度、曲线下面积高于或大于任一指标单独预测(均P<0.05),特异度差异则无统计学意义(P>0.05)。结论血清尿酸、TGF-β1、CA12-5水平在急性心肌梗死患者中异常升高,急性心肌梗死新发房颤患者的血清尿酸、TGF-β1、CA12-5水平更高,三者联合预测急性心肌梗死患者新发房颤的效能较好。
Objective To explore the expressions of serum uric acid,transforming growth factorβ1(TGF-β1)and carbohydrate antigen 12-5(CA12-5)in patients with acute myocardial infarction and the value of their combined prediction of new-onset atrial fibrillation.Methods A total of 364 patients with acute myocardial infarction were selected as the observation group,and 350 healthy check-up people were selected as the control group.The levels of serum uric acid,TGF-β1 and CA12-5 were detected in both groups.The patients were divided into the occurrence group or the non-occurrence group according to the presence of atrial fibrillation during hospitalization.The levels of serum uric acid,TGF-β1 and CA12-5 were compared between the two groups.The risk factors for new-onset atrial fibrillation in patients with acute myocardial infarction were analyzed by the Logistic regression model.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiency of the levels of serum uric acid,TGF-β1 and CA12-5 in the combined prediction of new-onset atrial fibrillation in patients with acute myocardial infarction.Results The levels of serum uric acid,TGF-β1 and CA12-5 in the observation group were higher than those in the control group(all P<0.05).There were 38 patients with new-onset atrial fibrillation in the observation group,with the incidence rate of 10.44%.Compared with the non-occurrence group,the occurrence group exhibited higher proportions of patients in age≥65 years old,and Killip grade≥Ⅱ,as well as higher levels of serum uric acid,TGF-β1 and CA12-5,while a lower left ventricular ejection fraction(all P<0.05).The Logistic regression analysis revealed that age≥65 years old,Killip grade≥Ⅱ,and high levels of serum uric acid,TGF-β1 and CA12-5 were the risk factors for new-onset atrial fibrillation in patients with acute myocardial infarction,and the elevation of left ventricular ejection fraction was the protective factor(all P<0.05).The results of the ROC curve analysis depicted that the sensitivit
作者
刘晓晨
杨威
LIU Xiao-chen;YANG Wei(Department of Critical Care Medicine,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)
出处
《广西医学》
CAS
2022年第16期1831-1835,共5页
Guangxi Medical Journal
基金
黑龙江省卫生计生委科研课题(2018088)。
关键词
急性心肌梗死
新发房颤
尿酸
转化生长因子Β1
糖类抗原12-5
预测效能
Acute myocardial infarction
New-onset atrial fibrillation
Uric acid
Transforming growth factorβ1
Carbohydrate antigen 12-5
Predictive efficiency
