摘要
目的探究血清癌胚抗原相关黏附分子1(CEACAM1)、糖类抗原125(CA125)与急性心肌梗死(AMI)患者心功能及预后的关系。方法选取2017年1月至2019年1月西安急救中心西安航天总医院收治的86例AMI患者纳入AMI组,另选取同期健康体检者86例纳入对照组。收集AMI患者及健康体检者一般临床资料、CEACAM1、CA125、超声心电图检查结果,以及AMI患者随访6个月内主要不良心脏事件(MACE)发生情况。结果AMI组总胆固醇、低密度脂蛋白、中心静脉压水平高于对照组,左室射血分数(LVEF)水平低于对照组,差异均有统计学意义(P<0.05)。AMI组血清CEACAM1、CA125水平明显高于对照组,差异有统计学意义(P<0.05)。Pearson相关分析显示,AMI组患者血清CEACAM1与CA125呈正相关(r=0.689,P<0.001)。根据AMI组患者血清CEACAM1水平的中位数(5103 pg/mL)和CA125水平的中位数(56 U/mL)进行分组,CEACAM1高水平组CEACAM1≥5103 pg/mL,CEACAM1低水平组CEACAM1<5103 pg/mL,CA125高水平组CA125≥56 U/mL,CA125低水平组CA125<56 U/mL。术后1周,CEACAM1高水平组与CA125高水平组患者LVEF分别明显低于CEACAM1低水平组和CA125低水平组,差异有统计学意义(P<0.05)。随访6个月期间,CEACAM1高水平组与CA125高水平组患者MACE发生率分别明显高于CEACAM1低水平组和CA125低水平组患者,差异有统计学意义(P<0.05)。结论AMI患者血清CEACAM1与CA125呈正相关,且其水平升高与AMI患者心功能不全和不良预后密切相关。
Objective To explore the relationship between serum carcinoembryonic antigen associated adhesion molecule 1(CEACAM1),carbohydrate antigen 125(CA125)and cardiac function,prognosis after acute myocardial infarction(AMI).Methods From January 2017 to January 2019,86 patients with AMI admitted to First Aid Station of Xi′an Aerospace General Hospital,Xi′an Emergency Center were selected as AMI group(86 cases),and 86 cases who received physical examination at the same time were selected as control group(86 cases).The general clinical data,laboratory indexes(including CEACAM1 and CA125),the results of ECG of all the subjects and the incidence of major adverse cardiac events(MACE)of AMI patients were collected.Results The level of total cholesterol,low-density lipoprotein,central venous pressure in AMI group were higher than those in control group,and the level of left ventricular ejection fraction(LVEF)was lower than that in control group(P<0.05).The serum CEACAM1 and CA125 levels in AMI group were significantly higher than those in control group(P<0.05).Pearson correlation analysis showed that serum CEACAM1 positively correlated with CA125(r=0.689,P<0.001).According to the median level of serum CEACAM1(5103 pg/mL)and CA125(56 U/mL),patients in AMI group were divided into high-level CEACAM1 group(CEACAM1≥5103 pg/mL),low-level CEACAM1 group(CEACAM1<5103 pg/mL),high-level CA125 group(CA125≥56 U/mL),low-level CA125 group(CA125<56 U/mL).One week after the operation,the LVEF in high-level CEACAM1 group and high-level CA125 group were significantly lower than those in low-level CEACAM1 group and low-level CA125 group(P<0.05).During the 6-month follow-up,the incidence of MACE in high-level CEACAM1 group and high-level CA125 group were significantly higher than those in low-level CEACAM1 group and low-level CA125 group(P<0.05).Conclusion Serum CEACAM1 positively correlated with CA125 in AMI patients,and the increase of serum CEACAM1 and CA125 closely related to cardiac dysfunction and poor prognosis.
作者
向祖琼
秦沛
XIANG Zuqiong;QIN Pei(First Aid Station of Xi′an Aerospace General Hospital,Xi′an Emergency Center,Xi′an,Shaanxi 710018,China;First Aid Station of Chengdong Branch Center,Xi′an Emergency Center,Xi′an,Shaanxi 710018,China)
出处
《检验医学与临床》
CAS
2021年第4期493-496,共4页
Laboratory Medicine and Clinic
关键词
癌胚抗原相关黏附分子1
糖类抗原125
急性心肌梗死
心功能
预后
carcinoembryonic antigen associated adhesion molecule 1
carbohydrate antigen 125
acute myocardial infarction
cardiac function
prognosis
