摘要
目的 观察黄芩清热除痹胶囊联合湿热痹阻外洗方治疗类风湿关节炎湿热痹阻证的临床疗效。方法回顾性分析2019年8月至2020年8月安徽中医药大学第一附属医院风湿免疫科门诊收治的60例类风湿关节炎湿热痹阻证患者的临床资料,根据治疗方法不同分为对照组和治疗组,各30例。2组均采用甲氨蝶呤治疗,在此基础上,治疗组予黄芩清热除痹胶囊联合湿热痹阻外洗方治疗。治疗4周后比较2组的临床疗效,治疗前后的关节肿胀数、关节压痛数、晨僵时间、视觉模拟评分法(VAS)评分,以及血沉(ESR)、超敏C反应蛋白(hs-CRP)、类风湿因子(RF)水平。结果 治疗组总有效率为93.3%(28/30),对照组为73.3%(22/30),2组比较差异有统计学意义(P<0.05);治疗后2组患者关节肿胀数、关节压痛数明显减少,晨僵时间明显缩短,VAS评分及ESR、hs-CRP、RF水平明显降低,与同组治疗前比较差异均有统计学意义(P<0.05),且治疗组作用更明显,与对照组治疗后比较差异均有统计学意义(P<0.05);2组不良反应发生率(均为3.3%)比较,差异无统计学意义(P>0.05)。结论 黄芩清热除痹胶囊联合湿热痹阻外洗方能明显改善类风湿关节炎湿热痹阻证患者的临床症状及体征,降低类风湿相关血液指标,疗效显著,且安全性高,值得临床推广应用。
Objective To observe the clinical efficacy of Huangqin Qingre Chubi Jiaonang(黄芩清热除痹胶囊,HQQRCBJN)combined with Shire Bizu Waixi Fang(湿热痹阻外洗方,SRBZWXF)in the treatment of rheumatoid arthritis(RA)with damp-heat bi-obstructing syndrome.Methods From August 2019 to August 2020,a retrospective study was undertake to analyze the clinical data of 60 cases of RA with damp-heat bi-obstructing syndrome admitted into outpatient service in rheumatology and immunology department of the First Affiliated Hospital of Anhui University of Chinese Medicine,who were divided into control group and treatment group according to different therapeutic methods,with 30 cases in each group.Both groups were treated with methotrexate,on this basis,the treatment group was given HQQRCBJN combined with SRBZWXF.After 4 weeks of treatment,the clinical efficacy,and joint swelling number,joint tenderness number,morning stiffness time,visual analogue scale(VAS)score,the levels of erythrocyte sedimentation rate(ESR),high sensitivity C-reactive protein(hs-CRP)and rheumatoid factors(RF)before and after treatment were compared between the 2 groups.Results The total effective rate of the treatment group was 93.3%(28/30),that of the control group was 73.3%(22/30),and the difference was statistically significant between the 2 groups(P<0.05).After treatment,the number of joint swelling and joint tenderness significantly decreased,morning stiffness time significantly shortened,and VAS score,the levels of ESR,hs-CRP and RF significantly decreased in the 2 groups,and the difference was statistically significant as compared with the same group before treatment(P<0.05),moreover,the effect was more significant in the treatment group,and the difference was statistically significant as compared with the control group after treatment(P<0.05).The difference was not statistically significant in adverse reactions(both 3.3%)between the 2 groups(P>0.05).Conclusion HQQRCBJN combined with SRBZWXF can markedly alleviate the clinical symptoms and sig
作者
丁本珺
黄传兵
付鹏
陈蕾蕾
DING Benjun;HUANG Chuanbing;FU Peng;CHEN Leilei(School of Postgraduate,Anhui University of Chinese Medicine,Hefei,Anhui,230038,China;Department of Rheumatology and Immunology,the First Affliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui,230031,China)
出处
《甘肃中医药大学学报》
2022年第4期53-57,共5页
Journal of Gansu University of Chinese Medicine
基金
国家自然科学基金面上项目(81473672)。
关键词
类风湿关节炎
湿热痹阻证
黄芩清热除痹胶囊
湿热痹阻外洗方
视觉模拟评分法评分
血沉
超敏C反应蛋白
类风湿因子
临床疗效
rheumatoid arthritis(RA)
damp-heat bi-obstructing syndrome
Huangqin Qingre Chubi Jiaonang(黄芩清热除痹胶囊,HQQRCBJN)
Shire Bizu Waixi Fang(湿热痹阻外洗方,SRBZWXF)
visual analogue scale(VAS)score
erythrocyte sedimentation rate(ESR)
high sensitivity C-reactive protein(hs-CRP)
rheumatoid factors(RF)
clinical efficacy
