摘要
回顾性总结5例门诊口服降糖药联合GLP-1受体激动剂(GLP-1RA)治疗控制不佳,转换为德谷胰岛素利拉鲁肽注射液联合二甲双胍和(或)钠?葡萄糖共转运蛋白2(SGLT2)抑制剂的成人2型糖尿病(T2DM)患者病例资料。随访发现,治疗1个月后患者空腹和餐后血糖均有明显改善,3个月时体重、腰围有一定程度的下降,均未出现低血糖发生和胃肠道不良反应,临床有效性和耐受性良好。
Retrospective review clinical data of 5 adult type 2 diabetic patients uncontrolled by oral antidiabetic drugs combined with GLP-1 receptor agonists in outpatient.After 1 month,both fasting and postprandial glucose improved after converting to insulin degludec and liraglutide (IDegLira) injection combined metformin with or without SGLT2 inhibitor.After 3 months,body weight loss and abdominal circumference loss were seen in most patients,that no hypoglycemia and gastrointestinal adverse events.In general,insulin degludec and liraglutide injection was effective and well-tolerated.
作者
于俊杰
马建华
YU Junjie;MA Jianhua(The 2nd Affiliated Hospital Of Harbin Medical University,Harbin Heilongjiang 150001,China;Nanjing First Hospital,Nanjing Jiangsu 210006,China.)
出处
《药品评价》
CAS
2022年第13期819-822,共4页
Drug Evaluation
