摘要
糖尿病心肌病是糖尿病患者严重的慢性不可逆心血管并发症之一。近年来研究发现,线粒体动力学平衡紊乱导致的线粒体功能障碍与糖尿病心肌病的发生密切相关。动力相关蛋白1(Drp1)是线粒体分裂的重要调节因子。研究表明,糖尿病心肌细胞中Drp1活性增强可导致线粒体分裂增加、融合减少,从而引起线粒体功能障碍。Drp1通过诱发心肌细胞氧化应激、能量代谢障碍、细胞凋亡、胰岛素抵抗和脂毒性,导致糖尿病心肌病的发生发展。此外,抑制Drp1的活性可改善糖尿病心肌病的心脏功能。本文对Drp1在糖尿病心肌病中的作用机制进行综述,以期为糖尿病心肌病的防治和药物研发提供新思路。
Diabetic cardiomyopathy is one of the chronic irreversible and serious cardiovascular complications in diabetic patients.Recent studies have shown that the mitochondrial dysfunction caused by the disturbance of mitochondrial dynamic balance is closely related to the occurrence of diabetic cardiomyopathy.Dynamin related protein 1(Drp1)is an important regulator of mitochondrial fission.Studies have shown that increased activity of Drp1 in diabetes cardiomyocytes can lead to increased mitochondrial fission and decreased mitochondrial fusion which leads to mitochondrial dysfunction.Drp1 can lead to the occurrence and development of diabetic cardiomyopathy by inducing oxidative stress,energy metabolism disorders,apoptosis,insulin resistance,and lipotoxicity in cardiomyocytes.In addition,inhibition of Drp1 activity may improve cardiac function in diabetic cardiomyopathy.Therefore,the mechanism of Drp1 in diabetic cardiomyopathy have been reviewed in present paper in order to provide new ideas for the prevention and treatment of diabetic cardiomyopathy and drug development.
作者
宋小刚
吴冰
陈永清
Song Xiao-Gang;Wu Bing;Chen Yong-Qing(Second Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730030,China;Department of Geriatrics,the 940th Hospital of Joint Logistics Support Force of Chinese PLA,Lanzhou,Gansu 730050,China;Department of Cardiology,Gansu Provincial Central Hospital,Lanzhou,Gansu 730070,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2022年第9期926-931,共6页
Medical Journal of Chinese People's Liberation Army
基金
甘肃省自然科学基金(18JR3RA402)
甘肃省卫生健康行业科研计划项目(GSWSKY2020-13)
西北民族大学课题(31920200012)。
关键词
线粒体分裂
动力相关蛋白1
糖尿病心肌病
心肌细胞
损伤机制
mitochondrial fission
dynamin related protein 1
diabetic cardiomyopathy
myocardial cell
damage mechanism
