摘要
目的探讨不同严重程度子痫前期(PE)患者心功能和血清炎性因子水平及与严重程度的相关性。方法选取2018年1月—2020年12月收治的130例PE为观察组,另外选取同期体检健康的130名志愿者为对照组。比较2组心脏超声指标和血清炎性因子水平,比较不同严重程度PE患者的心脏超声指标和血清炎性因子水平,并对心脏超声指标和血清炎性因子与PE严重程度的相关性进行分析,采用Spearman相关系数分析。结果观察组二尖瓣口舒张早期血流速度峰值/二尖瓣环根部运动速度峰值(E/Ea)、左心室基底部收缩期整体峰值旋转角度(BRmax)、心尖部收缩期整体峰值旋转角度(ARmax)、左心室收缩期峰值心肌扭转角度(Twistmax)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平显著高于对照组(P<0.01);轻度PE患者E/Ea、BRmax、ARmax、Twistmax、hs-CRP、TNF-α、IL-6水平显著低于重度PE患者(P<0.01)。E/Ea、BRmax、ARmax、Twistmax与PE严重程度呈显著正相关(r=0.421、0.476、0.511、0.564,P<0.001),hs-CRP、TNF-α、IL-6与PE严重程度呈显著正相关(r=0.397、0.466、0.549,P<0.001)。结论PE患者的E/Ea、BRmax、ARmax、Twistmax、hs-CRP、TNF-α、IL-6水平明显高于健康人群,且不同严重程度PE患者的上述指标水平也有显著差别。
Objective To investigate cardiac function and the levels of serum inflammatory factors in patients with different severity of preeclampsia(PE)and their correlation with the severity.Methods In total,130 cases of PE who were treated from January 2018 to December 2020 were selected as the observation group,and 130 healthy volunteers who had undergone physical examination during the same period were selected as the control group.The echocardiographic indexes and the levels of serum inflammatory factors of the two groups were compared,and the echocardiographic indexes and serum inflammatory factors of patients with different severity of PE were compared.The correlation between the echocardiographic indexes and the levels of serum inflammatory factors and the severity of PE was analyzed using Spearman correlation coefficient analysis.Results In the observation group,the peak diastolic blood flow velocity at the early stage of the mitral valve/the peak motion velocity of the mitral annulus root(E/Ea),the left ventricular systolic peak overall rotation Angle(BRmax),apex peak systolic overall rotation Angle(ARmax),left ventricular systolic peak myocardial torsion angle(Twistmax),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)levels were significantly higher than those in the control group(P<0.01).The levels of E/Ea,BRmax,ARmax,Twistmax,hs-CRP,TNF-α,and IL-6 in patients with mild PE were significantly lower than those in patients with severe PE(P<0.01).E/Ea,BRmax,ARmax,and Twistmax were significantly positively correlated with the severity of PE(r=0.421,0.476,0.511,0.564,P<0.001),and hs-CRP,TNF-α,and IL-6 were significantly positively correlated with the severity of PE(r=0.397,0.466,0.549,P<0.001).Conclusion The levels of E/Ea,BRmax,ARmax,Twistmax,hs-CRP,TNF-α,and IL-6 in PE patients were significantly higher than those in healthy people,and there were significant differences in the above indexes in PE patients with different severity.
作者
吕玲玲
崔微微
王亚静
王会敏
仝霞
LYU Ling-ling;CUI Wei-wei;WANG Ya-jing;WANG Hui-min;TONG Xia(Department of Obstetrics,People's Hospital of Dingzhou City,Dingzhou,Hebei 073000,China;Department of Obstetrics and Gynecology,the Seventh People's Hospital of Hebei Province,Dingzhou,Hebei 073000,China;Dressing Changing Room,Maternal and Child Health Hospital of Dingzhou City,Dingzhou,Hebei 073000,China)
出处
《解放军医药杂志》
CAS
2022年第7期67-70,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
河北省医学科学研究重点课题计划项目(20200398)。
