摘要
目的探讨长期情志不畅对认知功能的影响及其神经电生理机制。方法采用艾森克人格问卷(EPQ)成人版筛选符合高、低神经质标准的正常人群分别纳入长期情志不畅组和情志畅达对照组。使用蒙特利尔认知评估(MoCA)量表评估其总体认知功能;应用事件相关电位(ERPs)技术采集受试者完成色-词Stroop任务时的抑制控制的行为学和脑电数据,比较两组人群在色词一致和不一致条件下行为学及脑电波形潜伏期、波幅和面积。结果本研究共纳入受试者63对。每组受试者男20例、女43例;文化程度:初中15例(23.81%)、高中19例(30.16%)、大学29例(46.03%)。长期情志不畅组平均年龄(43.52±10.99)岁,情志畅达对照组平均年龄(43.44±11.06)岁。与情志畅达对照组比较,长期情志不畅组MoCA总分及视空间与执行功能认知域得分降低(P<0.05),其余认知域得分差异无统计学意义(P>0.05)。Stroop任务中,相较一致条件,受试者完成不一致条件时反应时更长、正确率更低(P<0.01);两组受试者Stroop任务不同条件下反应时差异均无统计学意义(P>0.05),但在色词不一致条件下,长期情志不畅组的正确率低于情志畅达对照组,差异呈边缘显著性(P=0.079);差异波(不一致条件减去一致条件)N450和冲突慢电位(冲突SP)峰值及潜伏期差异无统计学意义(P>0.05),长期情志不畅组N450面积大于情志畅达对照组(P<0.05)。结论长期情志不畅的正常人群已出现总体认知功能的加速衰退,对冲突的监测能力下降是其可能的机制之一。
Objective To explore the influence of long-term emotional disorder on cognitive function and its neuroelectrophysiological mechanism.Methods The adult version of Eysenck Personality Questionnaire(EPQ)was used to screen out normal people who met the criteria of high neuroticism into the emotional disorder group,and people who met the criteria of low neuroticism into the control group.The Montreal Cognitive Assessment(MoCA)scale was used to assess their overall cognitive function.Event-related potentials(ERPs)technology was used to collect behaviour and brain waves data of the inhibition control when completing the color-word Stroop task.The differences in behavior and brain waves form latency,amplitude and area of the two groups were compared under the conditions of consistent and inconsistent color words.Results A total of 63 people was included in each group,including 20 male and 43 female.In terms of the education level,15 cases(23.81%)were of junior high school level,19 cases(30.16%)were of high school level,and 29 cases(46.03%)were of college level.The age of the emotional disorder group was 43.52±10.99,while that of the control group was 43.44±11.06 years old.Compared to those in the control group,the total score of MoCA and the cognitive domain scores of visual space and executive function in the emotional disorder group were reduced(P<0.05),and there was no statistically significant difference in the scores of other cognitive domains(P>0.05).In the Stroop task,subjects completed the inconsistent condition task with longer response times and lower correct rates than the consistent condition(P<0.05).There was no statistically significant difference in the response time of both Stroop task conditions between the two groups(P>0.05),but under the condition of inconsistent color words,the correct rate of the emotional disorder group was lower than that of the control group,and the difference was marginally significant(P=0.079);the peak and latency differences of differential(inconsistent conditions minus consi
作者
詹向红
赵紫薇
刘永
侯俊林
王格格
许琳培
高安祺
秦中朋
霍磊
ZHAN Xianghong;ZHAO Ziwei;LIU Yong;HOU Junlin;WANG Gege;XU Linpei;GAO Anqi;QINZhongpeng;HUO Lei(Henan University of Chinese Medicine,Zhengzhou,450046;Henan Provincial Engineering Technology Research Center for Chinese and Western Integrative Prevention and Treatment of Brain Cognitive Disease;Zhengzhou Key laboratory for Chinese&Western Integrative Prevention and Treatment of Brain Cognitive Disease)
出处
《中医杂志》
CSCD
北大核心
2022年第16期1553-1558,共6页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81473556,81873208)。
关键词
阿尔茨海默病
情绪异常
高神经质
抑制控制
事件相关电位
Alzheimer’s disease
emotional disorder
high neuroticism
inhibition control
event-related potentials
