摘要
目的探讨愤怒情志与阿尔茨海默病(AD)的病因学关系,为愤怒长期积累可加速脑老化的论断提供流行病学依据。方法选取AD患者作为病例,以医院或社区无痴呆病、抑郁症等神经或精神疾病史者为对照,按同性别、同年龄段(±3岁)、同文化程度进行1∶1匹配的病例对照研究。调查方式为面对面访谈。结果 AD患者特质怒得分明显高于正常对照组(P<0.01);与正常对照组相比,高特质怒个体AD发病风险明显高于低特质怒个体(P<0.01),OR值(95%CI)为51.857(14.009,191.954);AD患者怒的表达(AX-O、AX-I)显著高于正常对照组(P<0.01),而怒的控制(AC-O、AC-I)显著低于正常对照组(P<0.01),AD患者怒表达指数显著高于正常对照组(P<0.01)。结论愤怒情志与AD发病相关,高特质怒是AD发病的危险因素;与正常人群相比,AD患者具有容易发怒或郁怒的倾向或特质,怒的表达程度高而控制力较弱。
Objective To investigate whether anger emotion is the risk factor of Alzheimer＇s disease （AD） , and for the long-term accumulation of anger can accelerate the aging brain to provide epidemiological basis. Methods AD patients were selected as case groups, the controls without dementia, depression, a history of neurological or psychiatric illness were selected as normal control groups in hospital or community, according to the same sex, same age （ ±3 years ） , and the same educational level, proceeded 1：1 matched the case-control study. Survey method was face to face interviews. Results Trait anger of AD patients scored significantly higher than that of normal control group （P 〈 0. 01 ）. Compared with normal control group, high trait anger individuals risk of AD was significantly higher than that of low trait anger individuals （P 〈 0. 01 ）. The OR value （95% CI） was 51. 857 （ 14. 009, 191. 954）. AD patients with anger expression （AX-O, AX- I） was significantly higher than that of normal control group （P 〈 0. 01 ）, and anger control （ AC-O, AC-I） was significantly lower than that of normal control group （P 〈 0. 01 ）, AD patients with anger expression index was significantly higher than that of normal control group （P 〈 0. 01 ）. Conclusions Anger emotion is associated with AD, high trait anger is the risk factor of AD. AD patients are more likely to tendency or character of anger expression-out or anger expression-in, they have the high level of anger expression and low controlled anger.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2012年第7期1453-1454,共2页
Chinese Journal of Gerontology
基金
国家自然科学基金资助项目(30772686,30973695)
