摘要
糖尿病视网膜病变(diabetic retinopathy,DR)作为糖尿病的常见微血管并发症,是多重因素、多个机制相互作用的结果,炎症是DR重要的病理、生理机制之一。白细胞聚集黏附于内皮细胞表面,胶质细胞激活和其功能障碍,血管内皮生长因子、白细胞介素等炎症因子的释放,均与DR炎症的发生、发展密切相关,抗炎成为治疗DR的重要切入点。研究表明中医药在靶向DR的炎症机制方面发挥独特优势,故对与DR密切相关的炎症细胞、炎症因子及相关中医药进行了综述,以期为DR的早期预防以及后期治疗提供参考。
Diabetic retinopathy(DR),as a common microvascular complication of diabetes,is the result of the interaction of multiple factors and multiple mechanisms.Inflammation is one of the important pathophysiological mechanisms of DR.Leukocytes accumulate and adhere to the surface of endothelial cells,glial cell activation and its dysfunction,and the release of vascular endothelial growth factor,interleukin and other inflammatory factors are directly related to the occurrence and development of DR inflammation.Antiinflammation plays an important role in the treatment of DR.Studies have shown that traditional Chinese medicine has a unique advantage in targeting the inflammatory mechanism of DR.Therefore,the inflammatory cells,inflammatory factors and related Chinese medicines closely related to DR are reviewed,in order to provide references for the early prevention and treatment of DR.
作者
朱琳
徐云生
ZHU Lin;XU Yun-sheng(The First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Endocrinology,the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,China)
出处
《海南医学院学报》
CAS
2022年第18期1435-1440,共6页
Journal of Hainan Medical University
基金
2018国家重点研发计划课题(2018YFC1704100,2018YFC1704103)。
关键词
糖尿病视网膜病变
炎症机制
中医药
Diabetic retinopathy
Inflammatory mechanism
Traditional Chinese medicine
