摘要
目的通过对《伤寒论》所载112首经方的近20年现代临床研究文献进行回顾性研究,揭示现代中医临床应用经方治疗病证的规律和用方安全情况。方法检索CNKI数据库中,自2000—2020年以来,以《伤寒论》经方为主方作为研究对象的现代中医临床研究文献,经文献筛选、病名规范分类后,采用文献计量法及内容分析法对所提取的数据加以统计处理。结果(1)最终共纳入3674篇文献,其中运用经方治疗脾胃系病证文献出现频数最高,为990篇(26.9%),治疗内科杂病文献次之,为893篇(24.3%);(2)在现代中医临床应用中,热度位居前10位的经方分别为半夏泻心汤、小柴胡汤、炙甘草汤、小青龙汤、柴胡加龙骨牡蛎汤、麻黄杏仁甘草石膏汤、真武汤、四逆散、大柴胡汤和当归四逆汤;(3)在治疗脾胃系病证中应用频数最高的经方为半夏泻心汤(84.7%),治疗内科杂病则为桂枝加葛根汤(92.0%),治疗肺系病证则为小青龙汤(96.1%),治疗心系病证则为炙甘草汤(95.2%),治疗外、妇、儿科病则为当归四逆汤(35.3%),治疗肝胆系病证则为大柴胡汤(42.6%),治疗肾系病证则为猪苓汤(51.3%);(4)有185篇(5.0%)文献记录了38首经方临床应用中的不良反应数据,出现频数位居前10位的经方,分别为小柴胡汤、半夏泻心汤、炙甘草汤、柴胡加龙骨牡蛎汤、小青龙汤、桂枝甘草龙骨牡蛎汤、黄连阿胶汤、五苓散、乌梅丸、麻黄杏仁甘草石膏汤。结论《伤寒论》所载经方可治疗的疾病种类,覆盖临床常见内、外、妇、儿科疾病,尤其在治疗脾胃系病证和内科杂病方面表现突出;经方在现代临床应用中存在个别不良反应,主要集中在少部分经方应用中,以胃肠道反应、皮肤反应以及头晕、口干等为表现。
Objective To study retrospectively the modern clinical research literature of 112 classical prescriptions in Treatise on Febrile Diseases in recent 20 years,and to reveal the rule and safety of modern Chinese medicine using classical prescriptions in the treatment of clinical diseases and syndromes.Methods From 2000 to 2020,modern Chinese medicine clinical research literature with the main prescription of"treatise on febrile diseases"as the research object was searched in CNKI database.After literature selection and standardized classification of disease names,the extracted data were statistically processed by bibliometric method and content analysis method.Results(1)A total of 3674 literatures were included for further exploration.The most frequent literatures were 990(26.9%)concerning spleen and stomach diseases,followed by 893(24.3%)concerning internal miscellaneous diseases.(2)In the clinical application of modern Chinese medicine,the top 10 classics with heat are Banxia Xiexin Decoction(半夏泻心汤),Xiaochaihu Decoction(小柴胡汤),Zhigancao Decoction(炙甘草汤),Xiaoqinglong Decoction(小青龙汤),Chaihu plus Longgu Muli Decoction(柴胡加龙骨牡蛎汤),Mahuang Xingren Gancao Shigao Decoction(麻黄杏仁甘草石膏汤),Zhenwu Decoction(真武汤),Sini Powder(四逆散),Dachaihu Decoction(大柴胡汤)and Danggui Sini Decoction(当归四逆汤).(3)In the treatment of spleen and stomach is the application of disease with the highest frequency by the parties to this Banxia Xiexin Decoction(84.7%),for Guizhi plus Gegen Decoction(桂枝加葛根汤)in treating internal medicine miscellaneous disease(92.0%)in the treatment of lung department of indication for Xiaoqinglong Decoction(96.1%),as the Zhigancao Decoction in treatment of heart diseases(95.2%)in the treatment of angelica sinensis in women over Danggui Sini Decoction(35.3%)in the treatment of diseases in liver for Dachaihu Decoction(42.6%)in the treatment of renal disease certificate for Zhuling Decoction(猪苓汤)(51.3%).(4)185(5.0%),paper
作者
赵文
吴长汶
周常恩
林雪娟
李磊
李灿东
ZHAO Wen;WU Changwen;ZHOU Chang'en;LIN Xuejuan;LI Lei;LI Candong(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China;Fujian Key Laboratory of TCM Health State,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,Fujian,China;Xiamen University,Xiamen 361005,Fujian,China)
出处
《辽宁中医药大学学报》
CAS
2022年第4期135-139,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金海峡联合基金(U1705286)
福建中医药大学校管科研课题(Χ2019016-平台)
福建中医药大学校管课题(X2021018)。
关键词
《伤寒论》
经方
临床应用
数据挖掘
Treatise on Febrile Diseases
classical prescriptions
clinical application
safety of prescription
data mining
