摘要
目的探讨伽玛刀立体定向放射治疗对早期非小细胞肺癌治疗效果及预后情况的影响。方法纳入郑州大学第五附属医院2010年6月至2017年6月收治的121例早期非小细胞肺癌患者,根据治疗方式的不同分为对照组和研究组,其中对照组60例患者采用常规分割放疗,研究组61例采用伽玛刀立体定向放射治疗,比较两组患者的有效率和局部控制率,统计两组患者放疗期间的副反应;比较研究组不同临床分期、不同病理类型和不同分化程度患者的有效率;对研究组患者开展为期5年的随访,比较治疗结束1年、结束3年和结束5年后不同临床分期患者生存率的差异。结果研究组治疗有效率(81.97%)和局部控制率(95.08%)均高于对照组(55.00%,73.33%),差异有统计学意义(P<0.05)。研究组放疗副反应发生率(11.48%)低于对照组(26.67%),差异有统计学意义(P<0.05)。研究组不同临床分期患者治疗有效率比较,差异无统计学意义(P>0.05)。研究组高分化鳞癌患者治疗有效率(92.31%)高于中低分化鳞癌患者(73.68%),差异有统计学意义(P<0.05)。研究组高分化腺癌患者有效率(100.00%)高于中低分化腺癌患者(70.59%),差异有统计学意义(P<0.05)。研究组Ⅰ期随访第3年和第5年的生存率虽均高于Ⅱ期患者,差异无统计学意义(P>0.05)。结论伽玛刀立体定向放射治疗早期非小细胞肺癌患者可以在提高近期治疗效果的同时也有助于提高患者的远期生存率,减少放疗期间副反应的发生,放疗安全性较高,值得应用。
Objective To investigate the effect and prognosis of gamma knife stereotactic radiotherapy on early stage non-small cell lung cancer(NSCLC).Methods A total of 121 patients with early-stage non-small cell lung cancer admitted to the Fifth Affiliated Hospital of Zhengzhou University from June 2010 to June 2017 were enrolled and divided into control group and study group according to different treatment methods.Sixty patients in the control group received conventional fractionated radiotherapy,while 61 patients in the study group received gamma knife stereotactic radiotherapy.The effective rate and local control rate of the two groups were compared,and the side effects during radiotherapy were counted.The effective rates of patients with different clinical stages,different pathological types and different degrees of differentiation were compared in the study group.Patients in the study group were followed up for 5 years,and the survival rates of patients in different clinical stages were compared at 1 year,3 years and 5 years after the end of treatment.Results The effective rate(81.97%)and local control rate(95.08%)of the study group were higher than those of the control group(55.00%,73.33%),and the differences were statistically significant(P<0.05).The incidence of side effects in the study group(11.48%)was lower than that in the control group(26.67%),and the difference was statistically significant(P<0.05).There was no significant difference in the effective rate of different clinical stages in the study group(P>0.05).In the study group,the effective rate of patients with well-differentiated squamous cell carcinoma(92.31%)was higher than that of patients with moderately and poorly differentiated squamous cell carcinoma(73.68%),and the difference was statistically significant(P<0.05).In the study group,the effective rate of well-differentiated adenocarcinoma patients(100.00%)was higher than that of moderately poorly differentiated adenocarcinoma patients(70.59%),and the difference was statistically significant(P<0.
作者
田碧
李朋朋
时昌立
丁广成
秦德华
卜亚静
TIAN Bi;LI Pengpeng;SHI Changli;DING Guangcheng;QIN Dehua;BU Yajing(Gamma knife center of the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450000,China)
出处
《临床研究》
2022年第10期39-42,共4页
Clinical Research
关键词
早期非小细胞肺癌
伽玛刀
立体定向放射治疗
生存率
副反应
early non-small cell lung cancer
gamma knife
stereotactic radiotherapy
survival rates
side reactions
