摘要
目的探讨肿瘤浸润淋巴细胞(TILs)在LuminalB型、人表皮生长因子受体2(Her-2)阳性[激素受体(HR)阳性]型乳腺癌中表达差异及与预后的关系。方法收集2015年1月至2016年2月徐州医科大学附属医院确诊并接受乳腺癌手术治疗的59例LuminalB型和46例Her-2阳性(HR阳性)型乳腺癌患者标本,并对所有研究对象的临床资料进行回顾性分析。比较LuminalB型、Her-2阳性(HR阳性)两种分型乳腺癌患者TILs的浸润水平,并分析TILs与两种分型乳腺癌患者预后的关系。结果Her-2阳性(HR阳性)型乳腺癌患者TILs的浸润水平低于LuminalB型(P<0.05)。LuminalB型、Her-2阳性(HR阳性)型乳腺癌复发组肿瘤分期为T3~T4期占比、TILs低/中等浸润占比均高于未复发组(P<0.05);经列联相关性分析LuminalB型、Her-2阳性(HR阳性)型乳腺癌5年复发情况与肿瘤分期、TILs浸润程度具有相关性(P<0.05)。TILs浸润程度为低/中等浸润的LuminalB型、Her-2阳性(HR阳性)型乳腺癌患者与高浸润患者复发曲线比较,差异均有统计学意义(P<0.05)。结论LuminalB型乳腺癌患者TILs浸润水平高于Her-2阳性(HR阳性)患者,且两种分型乳腺癌患者TILs浸润程度均与预后具有一定的相关性。
Objective To investigate the expression differences of tumor infiltrating lymphocytes(TILs)in LuminalB type and human epidermal growth factor receptor 2(Her-2)positive(hormone receptor[HR]positive)breast cancers and their relationship with prognosis.Methods Specimens from 59 cases of LuminalB type and 46 cases of Her-2 positive(HR positive)type breast cancer patients who were diagnosed and received surgical treatment of breast cancer in the Affiliated Hospital of Xuzhou Medical University from January 2015 to February 2016 were collected,and the clinical data were retrospectively analyzed.The infiltration levels of TILs in patients with two types of breast cancer,including Luminal B type and Her-2 positive(HR positive)were compared,and the relationship between TILs and the prognosis of patients with two types of breast cancer was analyzed.Results The infiltration level of TILs in patients with Her-2 positive(HR positive)breast cancer was lower than that of LuminalB(P<0.05).LuminalB and Her-2 positive(HR positive)breast cancer recurrence groups had higher tumor staging rates from T3 to T4,and the proportion of low/moderate infiltration of TILs were higher than those in the non-recurring group(P<0.05).The 5-year recurrence of LuminalB and Her-2 positive(HR-positive)breast cancers was correlated with tumor stage and the degree of TILs infiltration by contingency correlation analysis(P<0.05).The recurrence curves of LuminalB and Her-2 positive(HR positive)breast cancer patients with low/moderate infiltration degree of TILs were compared with high infiltration patients,and the difference was statistically significant(P<0.05).Conclusion The level of TILs infiltration in patients with Luminal B breast cancer is higher than that in patients with Her-2 positive(HR positive),and the degree of TILs infiltration in patients with two types of breast cancer has a certain correlation with the prognosis.
作者
马晓明
刘斌
MA Xiaoming;LIU Bin(Graduate School,Xuzhou Medical University,Jiangsu Province,Xuzhou 223001,China;Department of Oncology,Affiliated Hospital of Xuzhou Medical University,Jiangsu Province,Xuzhou 221006,China)
出处
《中国医药导报》
CAS
2022年第26期112-115,119,共5页
China Medical Herald
基金
江苏省科研与实践创新计划项目(SJCX18_0706)。
