摘要
目的探讨高强度重复经颅磁刺激(rTMS)治疗重度抑郁伴自杀意念患者的效果。方法选取2018年5月至2021年5月在浙江省宁波市精神病院接受治疗的重度抑郁伴自杀意念患者90例,采用随机数字表法将其分为高强度组、常规组和对照组,每组30例。在口服文拉法辛基础上,高强度组给予rTMS治疗(2次/d),常规组rTMS治疗(1次/d),两组每次治疗均为6000脉冲,对照组予伪刺激。观察三组治疗前后不同时间点的Beck自杀意念量表中文版(BSI-CV)、汉密尔顿抑郁评定量表24项(HAMD-24)评分。记录两组不良反应发生情况。结果本研究共脱落7例,其中高强度组3例,常规组2例,对照组2例。高强度组和常规组治疗第3天末的BSI-CV评分均低于治疗前,三组治疗第7天末BSI-CV评分均低于治疗第3天末,三组治疗第14天末BSI-CV评分均低于治疗第7天末(P<0.05)。高强度组治疗后第3、7、14天末的BSI-CV评分均低于同期常规组和对照组,常规组治疗后第3、7、14天末的BSI-CV评分均低于同期对照组(P<0.05)。三组治疗第7、14天末HAMD-24评分均低于治疗前,治疗第14天末低于治疗第7天末(P<0.05)。高强度组治疗第7、14天末HAMD-24评分均低于同期常规组和对照组,常规组第7、14天末HAMD-24评分低于同期对照组(P<0.05)。高强度组和常规组头痛发生率均高于对照组(P<0.017)。结论高强度rTMS治疗能迅速减轻重度抑郁患者的抑郁症状及自杀意念,效果优于常规治疗,是一种相对安全的治疗措施。
Objective To investigate the effect of high-intensity repetitive transcranial magnetic stimulation(rTMS)on patients with major depression and suicidal ideation.Methods A total of 90 patients with major depression and suicidal ideation admitted in Ningbo Mental Hospital of Zhejiang Province from May 2018 to May 2021 were selected and divided into high-intensity group,routine group,and control group by random number table method,with 30 cases in each group.On the basis of oral Venlafaxine,the high-intensity group was treated with rTMS(twice a day),and the routine group was treated with rTMS(once a day),each treatment in both groups was 6000 pulses,and the control group was treated with sham stimulation.The scores of Beck suicidal ideation scale Chinese version(BSI-CV)and Hamilton depression rating scale-24 items(HAMD-24)at different time points before and after treatment were observed.The occurrence of adverse reactions in the two groups was recorded.Results A total of seven cases fell off in this study,including three cases in the high-intensity group,two cases in the conventional group,and two cases in the control group.The BSI-CV scores at the end of the 3rd day of treatment in the high-intensity group and the routine group were lower than those before treatment,the BSI-CV scores of the three groups at the end of the 7th day of treatment were lower than those at the end of the 3rd day of treatment,and the BSI-CV scores of the three groups at the end of the 14th day of treatment were lower than those at the end of the seventh day of treatment(P<0.05).The BSI-CV scores of the high-intensity group at the end of the 3rd,7th,and 14th day of treatment were lower than those of the routine group and the control group at the same time,the BSI-CV scores of the routine group at the end of the 3rd,7th and 14th day of treatment were lower than those of the control group at the same time(P<0.05).The HAMD-24 scores of the three groups at the end of the 7th and 14th days of treatment were lower than those before treatment,and a
作者
李松华
付可登
胡媛媛
王健美
LI Songhua;FU Kedeng;HU Yuanyuan;WANG Jianmei(Department of Psychiatry,Ningbo Mental Hospital,Zhejiang Province,Ningbo 315032,China)
出处
《中国医药导报》
CAS
2022年第26期90-93,共4页
China Medical Herald
基金
浙江省医药卫生科技计划项目(2019KY201)。
关键词
重复经颅磁刺激
抑郁症
自杀意念
疗效
Transcranial magnetic stimulation
Depression
Suicide ideation
Curative effect
