摘要
微小RNA(miRNA)是非编码的短RNA,主要功能是特异性结合靶mRNA,抑制靶mRNA表达,在转录后水平对基因的表达进行调控,脓毒症是机体对感染的反应失调引起危及生命的器官功能障碍,具有发展快、预后差和病死率高的致病特点,目前研究表明miRNA在脓毒症细胞信号转导和调节免疫应答中发挥重要作用。近年来,针灸对脓毒症的防治作用愈发凸显,但其内在机理却仍不清晰。本研究对miRNA在脓毒症发生、发展中的机制进行综述,并探讨分析了针灸治疗脓毒症的作用机制,以期从miRNA出发为针灸治疗脓毒症的机制研究以及针灸学科的基因组学研究提供一个新的视角。
MicroRNA(miRNA)is small single-stranded noncoding RNA and can inhibit gene expression at the post-transcriptional level by binging to the target mRNA.Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection,which leads to tissue damage and organ dysfunction,and is characterized by rapid development,poor prognosis and high mortality.Current studies have shown that miRNA plays an important role in signal transduction and immune response regulation of sepsis cells.In recent years,the prevention and treatment effect of acupuncture on sepsis has become increasingly prominent,but its internal mechanism is still not clear.This study reviewed the mechanism of miRNA in the occurrence and development of sepsis,and the mechanism of acupuncture in treating sepsis was discussed and analyzed,in order to provide a new perspective for the study of acupuncutre mechanism in treating sepsis and for the genomics study of acupuncture from the aspect of miRNA.
作者
贾坤平
孙忠人
刘关平
裴思颖
蔡国锋
伊思锐
刘源
梁群
JIA Kunping;SUN Zhongren;LIU Guanping;PEI Siying;CAI Guofeng;YI Sirui;LIU Yuan;LIANG Qun(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《针灸临床杂志》
2022年第9期96-101,共6页
Journal of Clinical Acupuncture and Moxibustion
基金
黑龙江省自然科学基金,编号:H2018066
春晖计划,编号:HLJ2019031
黑龙江中医药大学科研基金,编号:2019MS19。
关键词
针灸
脓毒症
微小RNA
综述
Acupuncture and moxibustion
Sepsis
miRNA
Review
