摘要
目的:探讨腹腔镜手术对老年结肠癌患者的影响研究。方法:选取2017年6月-2018年7月广东省第二人民医院收治的85例老年结肠癌手术患者,根据手术方式将患者分为A组(n=43)和B组(n=42)。A组给予开腹结肠癌切除术,B组给予腹腔镜结肠癌切除术。比较两组临床指标、血清炎症因子、免疫指标、并发症发生情况及预后。结果:B组手术时间为(154.23±50.64)min,长于A组的(148.16±46.23)min,但差异无统计学意义(P>0.05)。B组术中出血量为(83.26±25.47)mL,少于A组的(129.36±49.31)mL,差异有统计学意义(P<0.05)。B组肛门排气时间为(56.24±13.26)h、住院时间(8.84±4.46)d,均短于A组的(79.41±22.15)h、(11.36±5.78)d,差异均有统计学意义(P<0.05)。术后1 d,B组白介素-6(IL-6)为(6.54±1.02)ng/L、C反应蛋白(CRP)为(31.87±5.74)mg/L,均低于A组的(8.16±1.14)ng/L、(50.84±7.63)mg/L,差异均有统计学意义(P<0.05)。术后3个月,B组CD4^(+)为(44.28±5.23)%、CD8^(+)为(35.27±4.58)%,均高于A组的(40.03±5.72)%、(30.24±4.26)%,差异均有统计学意义(P<0.05)。B组并发症发生率为14.29%,低于A组的37.21%,差异有统计学意义(P<0.05)。两组淋巴结清扫数目、生存率与复发率比较,差异均无统计学意义(P>0.05)。结论:腹腔镜手术可明显改善老年结肠癌患者临床指标、血清炎症因子、免疫指标水平,并降低患者并发症发生率,且其生存率、复发率与开腹手术并无明显差异。
Objective:To investigate the effect of laparoscopic surgery on elderly patients with colon cancer.Method:A total of 85 elderly patients with colon cancer underwent operation in the Guangdong Second People’s Hospital from June 2017 to July 2018 were selected,they were divided into group A(n=43)and group B(n=42)according to the operation method.Group A received open resection of colon cancer,group B received laparoscopic resection of colon cancer.The clinical indicators,serum inflammatory factors,immune indicators,complications and prognosis were compared between two groups.Result:The operation time of group B was(154.23±50.64)min,which was longer than(148.16±46.23)min of group A,but the difference was not statistically significant(P>0.05).The intraoperative blood loss of group B was(83.26±25.47)mL,which was less than(129.36±49.31)mL of group A,and the difference was statistically significant(P<0.05).The anal exhaust time and hospital stay of group B were(56.24±13.26)h and(8.84±4.46)d,which were shorter than(79.41±22.15)h and(11.36±5.78)d of group A,the differences were statistically significant(P<0.05).At 1 d after operation,the interleukin-6(IL-6)and C reactive protein(CRP)levels of group B were(6.54±1.02)ng/L and(31.87±5.74)mg/L,which were lower than(8.16±1.14)ng/L and(50.84±7.63)mg/L of group A,the differences were statistically significant(P<0.05).At 3 months after operation,CD4and CD8of group B were(44.28±5.23)%and(35.27±4.58)%,which were higher than(40.03±5.72)%and(30.24±4.26)%in group A,the differences were statistically significant(P<0.05).The complication rate of group B was 14.29%,which was lower than 37.21%of group A,the difference was statistically significant(P<0.05).There were no significant difference in the number of lymph nodes dissected,survival rate and recurrence rate between two groups(P>0.05).Conclusion:Laparoscopic surgery can significantly improve the levels of clinical indicators,serum inflammatory factors and immune indicators in elderly patients with colon cancer,and re
作者
余智涛
张磊
温建燔
YU Zhitao;ZHANG Lei;WEN Jianfan(Guangdong Second People’s Hospital,Guangzhou 510317,China;不详)
出处
《中国医学创新》
CAS
2022年第25期133-137,共5页
Medical Innovation of China
关键词
结肠癌
老年患者
腹腔镜
Colon cancer
Elderly patients
Laparoscopy
