摘要
目的:分析外周血异常糖链糖蛋白(TAP)联合人乳头瘤病毒(HPV)、细胞间黏附分子-1(ICAM-1)指标检测对围绝经期宫颈癌变患者术后复发的预测价值及与预后关系。方法:选择2020年1月-2021年1月在本院接受宫颈癌根治术的围绝经期患者132例,妇科检查健康妇女77例分别为宫颈癌组和对照组,检测宫颈癌组术前及对照组上述3项指标,术后随访1年,将宫颈癌组分为复发组及未复发组,比较临床病理资料、指标检测水平,分析TAP、HPV、ICAM-1检测预测术后复发效能,采用Spearman相关系数分析各指标与术后复发相关性。结果:宫颈癌组术前血清TAP、ICAM-1水平及高危型HPV阳性率均高于对照组,宫颈癌组术后12个月内复发患者血清TAP、ICAM-1及高危型HPV阳性率高于术后3个月,未复发组各指标水平低于术前及术后3个月时,复发组各指标水平均高于未复发组(均P<0.001)。3项指标联合检测的曲线下面积(AUC)=0.979,高于单项指标检测;Spearman相关系数分析显示,血清TAP、ICAM-1水平及高危型HPV阳性率与患者术后预后呈明显正相关(均P<0.05)。结论:TAP、ICAM-1、高危型HPV检测对围绝经期宫颈癌根治患者术后复发预测具有一定效用,且3项指标水平均与患者手术预后相关,提示临床对宫颈癌患者术后加强有关指标检测,提高手术治疗效果及患者生存。
Objective: To analyze the predictive value of the peripheral blood abnormal glycochain glycoprotein(GGP) level combined with the positive rate of human papillomavirus(HPV) and the intercellular adhesion molecule-1(ICAM-1) level for the postoperative recurrence of cervical cancer of perimenopausal women, and to study its correlation with the prognosis of the patients. Methods: A total of 132 perimenopausal women who wanted radical cervical cancer surgery were selected in study group from January 2020 to January 2021. 77 healthy women who had accepted gynecological examination were selected in control group during the same period. The peripheral blood abnormal GGP level, and the positive rate of HPV, and the level of ICAM-1 of the women in the study group before surgery and the women in the control group were detected. The women in the study group were further divided in group A(women with the postoperative recurrence of cervical cancer) and group B(women without the postoperative recurrence of cervical cancer) after 1 year of follow up. The clinicopathological data and the levels of GGP and ICAM-1, and the positive rate of HPV of the women were compared between group A and group B. The efficacy of the levels of TAP and ICAM-1, and the positive rate of HPV for predicting the postoperative recurrence of cervical cancer of the women was analyzed. Spearman correlation coefficient was used to analyze the correlation between the positive rate of HPV and the GGP and ICAM-1 levels of the women and their p ostoperative recurrence of cervical cancer.Results:The serum TAP and ICAM-1 levels and the positive rate of high-risk HPV of the women in the study group were significantly higher than those of the women in the control group before surgery(all P<0.001).The serum TAP and ICAM-1 levels and the positive rate of high-risk HPV of the women with recurrence in 12 months after surgery in the study group were significantly higher than those of the women with recurrence in 3 months after surgery.The serum TAP and ICAM-1 levels,and
作者
杨雅楼
何明欣
李珑
胡璇
YANG Yalou;HE Mingxin;LI long;HU Xuan(Hainan Medical College,Haikou,Hainan Province,571199;The Second Affiliated Hospital of Hainan Medical College;The First People's Hospital of Tianmen of Hubei Province)
出处
《中国计划生育学杂志》
2022年第8期1740-1744,共5页
Chinese Journal of Family Planning
基金
国家卫生健康热带病防治重点实验室青年基金项目(2021NHCTDCKFKT21008)
海南医学院研究生创新科研课题(HYYS2020-13)。
关键词
宫颈癌根治术
异常糖链糖蛋白
人乳头瘤病毒
细胞间黏附分子-1
术后复发
预后
Radical resection surgery of cervical cancer
Abnormal glycochain glycoprotein
Human papillomavirus
Intercellular adhesion molecule-1
Postoperative recurrence
Prognosis
