摘要
目的 探讨衡阳市农村地区人乳头瘤病毒(HPV)感染和宫颈病变现状,分析其影响因素,为制订宫颈癌防控策略提供科学依据。方法 选取2020年1月1日—12月31日衡阳市2个农村项目县的35~64岁妇女10 293例宫颈癌筛查人员为研究对象,均进行高危型HPV检测、宫颈薄层液基细胞学检查(TCT)、阴道镜及组织病理检查,计算HPV阳性检出率、宫颈癌前病变和宫颈癌检出率及早诊率,分析HPV感染和宫颈病变的相关影响因素。结果 HPV阳性检出率为15.37%,55~59岁年龄组的HPV阳性检出率最高。宫颈病变共检出225例,其中低级别鳞状上皮内病变(CINⅠ)127例、高级别鳞状上皮内病变(CINⅡ/Ⅲ)94例及浸润性宫颈癌4例;宫颈癌前病变检出率为913.24/10万,宫颈癌检出率为38.86/10万,早期诊断率为95.92%。HPV感染的危险因素包括年龄增长[OR=1.038(1.030~1.046)]、宫颈柱状上皮异位[OR=1.207(1.021~1.426)]、孕次>3次[OR=1.530(1.194~1.948)]、滴虫性阴道炎[OR=2.079(1.371~3.154)]、宫颈炎[OR=1.275(1.069~1.520)]及细菌性阴道病[OR=1.340(1.054~1.703)];宫颈病变的危险因素主要为年龄增长[OR=1.049(1.029~1.070)]、生殖道感染[OR=1.389(1.048~1.842)]及孕次>3次[OR=3.619(1.893~6.919)]。结论 衡阳市农村妇女HPV感染阳性率较高,应给予更多关注。年龄增长、宫颈柱状上皮异位、孕次>3次、滴虫性阴道炎、宫颈炎及细菌性阴道病均为HPV感染的危险因素;年龄增长、生殖道感染及孕次>3次均是宫颈病变的危险因素。
Objective To investigate the current situation of human papillomavirus(HPV) infection and cervical lesions in rural areas of Hengyang City, analyze the influencing factors, and provide a scientific basis for formulating a strategy for prevention and control of cervical cancer.Methods From 1 st January to 31 st December 2020, the screening data were collected from 10 293 women aged 35-64 years old in two rural project districts of Hengyang City, including high-risk HPV(HR-HPV) test results, ThinPrep cytology test(TCT), colposcopy and histopathology.The positive detection rate of HPV, the detection rates of cervical precancerous lesions and cervical cancer, and the early diagnostic rate were calculated, with the aim of analyzing the factors influencing HPV infection and cervical lesions.Results The positive detection rate of HPV was 15.37%, which was the highest among the women in 55-59 age group.A total of 225 cases of cervical lesions were detected, including 127 cases of CIN I, 94 cases of CIN II/III, and 4 cases of invasive cervical cancer;the detection rate of cervical precancerous lesions was 913.24/100 000, the detection rate of cervical cancer was 38.86/100 000, and the early diagnostic rate was 95.92%.The risk factors for HPV infection were age [OR=1.038(1.030-1.046)], ectopic cervical columnar epithelium [OR= 1.207(1.021-1.426)],times of pregnancy>3 [OR=1.530(1.194-1.948)], trichomonal vaginitis [OR= 2.079(1.371-3.154)], cervicitis [OR= 1.275(1.069-1.520)], and bacterial vaginosis [OR=1.340(1.054-1.703)];the main risk factors for cervical lesions were age [OR= 1.049(1.029-1.070)], reproductive tract infections [OR= 1.389(1.048-1.842)], and times of pregnancy>3 [OR= 3.619(1.893-6.919)].Conclusion The positive rate of HPV infection among rural women in this town is high, more attention should be paid to.Age, ectopic cervical columnar epithelium, gestational periods > 3,trichomonal vaginitis, cervicitis and bacterial vaginosis are the risk factors for HPV infection.Age, reproductive tract infections and preg
作者
肖岚
吴成秋
张羽
常雪晴
姜泽鑫
XIAO Lan;WU Cheng-Qiu;ZHANG Yu(School of Public Health,University of South China,Hengyang,Hu'nan 421600;Department of Women's Health Care,Hengyang Maternal and Child Health Care Hospital,Hengyang,Hu'nan 421600,China)
出处
《中国妇幼保健》
CAS
2022年第15期2853-2857,共5页
Maternal and Child Health Care of China
关键词
宫颈癌
宫颈病变
人乳头瘤病毒
影响因素
Cervical cancer
Cervical lesions
Human papillomavirus
Influence factor
