摘要
目的 探讨银杏达莫注射液联合高压氧治疗老年痴呆患者的效果。方法 80例老年痴呆患者,通过双盲法分为观察组和对照组,各40例。对照组采用高压氧治疗,观察组在对照组基础上加用银杏达莫注射液治疗。比较两组临床疗效,治疗前后血清钙结合蛋白(S100B)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)水平,治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]水平,不良反应发生情况。结果 观察组患者的总有效率95.00%明显高于对照组的77.50%,差异具有统计学意义(P<0.05)。治疗后,观察组患者的S100B(316.52±26.86)μg/ml、NSE(25.62±4.11)U/ml、MBP(96.36±8.43)pg/ml均显著低于对照组的(405.64±31.51)μg/ml、(34.62±4.74)U/ml、(125.37±10.05)pg/ml,差异具有统计学意义(P<0.05)。治疗后,观察组患者的TNF-α(1.34±0.64)ng/L、IL-6(81.06±9.25)ng/L均明显低于对照组的(2.52±0.78)、(103.73±10.17)ng/L,差异具有统计学意义(P<0.05)。观察组患者的不良反应发生率为10.00%,与对照组的5.00%比较,差异无统计学意义(P>0.05)。结论 老年痴呆患者采用银杏达莫注射液与高压氧联合治疗,能够提升疗效,改善神经损伤,可抑制炎症反应,不良反应少,安全性较高。
Objective To discuss the effect of ginkgo leaf extract and dipyridamole injection combined with hyperbaric oxygen in the treatment of senile dementia patients. Methods A total of 80 patients with Alzheimer’s disease were divided into observation group and control group by double-blind method, with 40 cases in each group. The control group was treated with hyperbaric oxygen, and the observation group was additionally treated with ginkgo leaf extract and dipyridamole injection on the basis of the control group. Both groups were compared in terms of clinical efficacy, serum calcium-binding protein(S100B), neuron-specific enolase(NSE),myelin basic protein(MBP), and inflammatory factors [tumor necrosis factor-α(TNF-α), interleukin-6(IL-6)] before and after treatment, and the occurrence of adverse reactions. Results The total effective rate 95.00% in the observation group was significantly higher than 77.50% in the control group, and the difference was statistically significant(P<0.05). After treatment, the S100B(316.52±26.86) μg/ml, NSE(25.62±4.11) U/ml and MBP(96.36±8.43) pg/ml in the observation group were significantly lower than(405.64±31.51) μg/ml,(34.62±4.74) U/ml and(125.37±10.05) pg/ml in the control group, and the differences were statistically significant(P<0.05). After treatment, the TNF-α(1.34±0.64) ng/L and IL-6(81.06±9.25) ng/L in the observation group were significantly lower than(2.52±0.78) and(103.73±10.17) ng/L in the control group, and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 10.00%, which was not statistically significant compared with 5.00% in the control group(P>0.05). Conclusion The combination of ginkgo leaf extract and dipyridamole injection and hyperbaric oxygen can improve the clinical efficacy, improve nerve injury, inhibit inflammatory reaction, with less adverse reactions and high safety.
作者
马直勉
张晓璐
徐广玲
MA Zhi-mian;ZHANG Xiao-lu;XU Guang-ling(Northeast Forestry University Hospital,Harbin 150040,China)
出处
《中国实用医药》
2022年第18期46-49,共4页
China Practical Medicine
关键词
银杏达莫注射液
高压氧
老年痴呆
Ginkgo leaf extract and dipyridamole injection
Hyperbaric oxygen
Senile dementia
