摘要
目的分析多巴胺受体激动剂治疗小儿多动症的临床疗效和安全性。方法130例多动症患儿,随机分为对照组和观察组,每组65例。对照组患儿给予常规多动症药物治疗,观察组患儿给予多巴胺受体激动剂治疗。比较两组患儿Conners儿童行为量表评分、临床疗效及不良反应发生情况。结果观察组患儿学习行为、心身行为、冲动行为、品行行为评分和多动指数分别为(1.08±0.42)、(0.23±0.20)、(0.82±0.39)、(0.83±0.27)、(1.04±0.39)分,均显著低于对照组的(1.71±0.60)、(0.72±0.51)、(1.81±0.86)、(1.42±0.53)、(2.03±0.75)分,差异有统计学意义(P<0.05)。观察组治疗总有效率92.31%高于对照组的76.92%,差异有统计学意义(P<0.05)。观察组不良反应发生率6.15%显著低于对照组的18.46%,差异有统计学意义(P<0.05)。结论对小儿多动症应用多巴胺受体激动剂治疗可以明显提升临床疗效,且总体安全性较好,是一种比较理想的治疗药物,值得临床推广应用。
Objective To analyze the clinical efficacy and safety of dopamine receptor agonists in the treatment of attention deficit hyperactivity disorder in children.Methods A total of 130 children with ADHD were randomly divided into control group and observation group,with 65 cases in each group.Children in the control group received conventional ADHD drug treatment,while children in the observation group received dopamine receptor agonist therapy.The scores of Conners'Parent Rating scale,clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results The scores of learning behavior,psychosomatic behavior,impulsive behavior,conduct behavior and hyperactivity index in the observation group were(1.08±0.42),(0.23±0.20),(0.82±0.39),(0.83±0.27),and(1.04±0.39)points,which were significantly lower than(1.71±0.60),(0.72±0.51),(1.81±0.86),(1.42±0.53),and(2.03±0.75)points in the control group,and the differences were statistically significant(P<0.05).The total effective rate 92.31%of the observation group was higher than 76.92%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 6.15%,which was significantly lower than 18.46%in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of dopamine receptor agonists in the treatment of children with ADHD can significantly improve the clinical efficacy,and the overall safety is good.It is an ideal treatment drug and is worthy of clinical promotion and application.
作者
靖杰
JING Jie(Department of Pediatrics,Shenyang Fifth People's Hospital,Shenyang 110000,China)
出处
《中国现代药物应用》
2022年第15期153-155,共3页
Chinese Journal of Modern Drug Application
关键词
小儿多动症
多巴胺受体激动剂
盐酸哌甲酯缓释片
吡贝地尔缓释片
Attention deficit hyperactivity disorder in children
Dopamine receptor agonists
Methylphenidate hydrochloride prolonged-release tablets
Piribedil sustained-release tablets
