摘要
目的探讨静灵口服液联合中枢神经兴奋剂对儿童注意缺陷多动障碍疗效观察及对儿童行为和血清25-羟维生素D3水平的影响。方法选择2019年3月至2020年3月于嘉兴市第二医院就诊的小儿多动症160例作为研究对象,按照随机数字表法分为观察组80例与对照组80例。对照组给予中枢神经兴奋剂(盐酸哌甲酯缓释片)治疗,观察组在对照组基础上结合静灵口服液治疗,两组疗程均为12周。比较两组治疗12周后总有效率,治疗前与治疗12周后Conners儿童行为量表评分、主要症状积分、血清多巴胺和25-羟维生素D3水平变化。结果观察组治疗12周后总有效率显著高于对照组(92.50%vs.77.50%,χ^2=7.059,P<0.05);两组治疗12周后Conners儿童行为量表评分中的身心问题、学习问题、冲动多动和品行问题较治疗前均降低,且观察组治疗12周后评分均低于对照组(t值分别为13.492、13.679、14.848、22.624,均P<0.05);两组治疗12周后神思涣散、多动多语、小动作多及坐立不安症状积分较治疗前均降低,且观察组治疗12周后积分低于对照组(t值分别为13.700、13.877、14.618、14.926,均P<0.05);两组治疗12周后血清多巴胺和25-羟维生素D3水平较治疗前均升高,且观察组治疗12周后水平高于对照组(t值分别为33.505、17.352,均P<0.05)。结论静灵口服液联合中枢神经兴奋剂对儿童注意缺陷多动障碍疗效良好,且可改善患儿行为,提高血清多巴胺和25-羟维生素D3水平。
Objective To observe therapeutic effect of Jingling oral liquid combined with central nervous stimulant on children with attention deficit hyperactivity disorder(ADHD)and effects of the combined therapy on their behaviors and serum 25 hydroxyvitamin D3 level.Methods 160 children with ADHD who were treated in The Second Jiaxing Municipal Hospital from March 2019 to March 2020 were selected as the research subjects and they were randomly divided into observation group(80 cases)and control group(80 cases).The children with ADHD in the control group were treated with central nervous stimulant methylphenidate hydrochloride slow-releasing tablet,and those children with ADHD in the observation group were treated with Jingling oral liquid combined with central nervous stimulant methylphenidate hydrochloride slow-releasing tablet as in the control group.The course of treatment was 12 weeks for the children in both groups.After 12 weeks of treatment,the total effective rate,scores in Conners child behavior scale,scores in the main symptoms,serum levels of dopamine and 25 hydroxyvitamin D3 were compared with those before the tratment.Results After 12 weeks of treatment,the total effective rate in the observation group was higher than that in the control group(92.50%vs.77.50%,χ^2=7.059,P<0.05).And the scores in physical and mental problems,learning problems,impulsive hyperactivity and conduct problems in Conners children’s behavior scale of the children in the two groups were lower than those before treatment(all P<0.05),and these scores of the children in the observation group after 12 weeks of treatment were lower than those of the children in the control group after 12 weeks of treatment(t=13.492,13.679,14.848 and 22.624 respectively,all P<0.05).Furthermore,after 12 weeks of treatment,the scores in mental distraction,hyperactivity and verbose,phaneromania and restlessness of the children in the two groups were lower than those before treatment(all P<0.05),and these scores of the children in the observation group were l
作者
徐凌燕
滕懿群
XU Lingyan;TENG Yiqun(Department of Pediatrics,The Second Jiaxing Municipal Hospital,Zhejiang Jiaxing 314000,China)
出处
《中国妇幼健康研究》
2020年第10期1388-1392,共5页
Chinese Journal of Woman and Child Health Research
关键词
静灵口服液
中枢神经兴奋剂
儿童注意缺陷多动障碍
疗效
儿童行为
25-羟维生素D3
Jingling oral liquid
central nervous stimulant
attention deficit hyperactivity disorder(ADHD)
therapeutic effect
children’s behavior
25 hydroxyvitamin D3
