摘要
目的探讨CD64指数、人中性粒细胞载脂蛋白及降钙素原(PCT)对慢性阻塞性肺疾病急性加重期(AECOPD)患者细菌感染诊断价值。方法选择2019年5年至2021年3月在湖南省胸科医院接受治疗的97例AECOPD患者为观察组,以性别、年龄(±5岁)进行1∶1配对选取同期在该院接受健康体检的97例健康人群为对照组。抽取调查对象空腹外周静脉血5 mL,对CD64指数、人中性粒细胞载脂蛋白及PCT进行检测。比较观察组与对照组上述各实验室指标水平。根据有无呼吸道感染将观察组患者分为细菌感染组与非细菌感染组,比较2组患者上述各指标,并采用ROC分析法判断各指标单独检测及联合检查的对AECOPD患者细菌感染的诊断价值。结果观察组CD64指数、人中性粒细胞载脂蛋白及PCT水平均高于对照组(P<0.05)。细菌感染组者CD64指数、人中性粒细胞载脂蛋白及PCT水平均高于非细菌感染组(P<0.05)。ROC分析结果显示:CD64指数、人中性粒细胞载脂蛋白及PCT对AECOPD患者细菌感染诊断的cut-off值分别为12.95%、82.04μg/L、1.65 ng/L;曲线下面积(AUC)分别为0.883、0.806、0.759。三者联合诊断(指AECOPD患者CD64指数、人中性粒细胞载脂蛋白及PCT联合检测时其中1个指标高于cut-off值即判断为细菌感染)的AUC为0.924,其诊断效能高于各指标单独(P<0.05)。结论健康人群、AECOPD细菌感染者及AECOPD非细菌感染者CD64指数、人中性粒细胞载脂蛋白及PCT具有显著性差异,三种指标均可用作诊断AECOPD患者细菌感染,三者联合检测可提高诊断效能。
Objective To investigate the diagnostic value of CD64 index,human neutrophil apolipoprotein and procalcitonin(PCT)in the diagnosis of bacterial infection in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 97 patients with AECOPD who were treated in our hospital from May 2019 to March 2021 were selected as the observation group,and 97 healthy people who received physical examination in our hospital during the same period were selected as the control group by 1:1 pairing of gender and age(±5 years old).Five ml of fasting peripheral venous blood was taken from the subjects to detect CD64 index,human neutrophil apolipoprotein and PCT.The levels of the above-mentioned laboratory indicators between the observation group and the control group were compared.According to the presence or absence of respiratory tract infection,the observation group was divided into a bacterial infection group and a non-bacterial infection group.The above indicators of the two groups were compared,and the ROC analysis method was used to determine the diagnostic value of individual detection alone and combined examination for bacterial infection in AECOPD patients.Results The levels of CD64 index,human neutrophil apolipoprotein and PCT in the observation group were higher than those in the control group(P<0.05).The levels of CD64 index,human neutrophil apolipoprotein and PCT in the bacterial infection group were higher than those in the non-bacterial infection group(P<0.05).ROC analysis showed that the cut-off values of CD64 index,human neutrophil apolipoprotein and PCT in the diagnosis of bacterial infection in AECOPD patients were 12.95%,82.04μg/L,and 1.65 ng/L,respectively.The values of the area under the curve(AUC)were 0.883,0.806 and 0.759,respectively.The AUC of the combined detection of CD64 index,human neutrophil apolipoprotein and PCT in AECOPD patients was 0.924,which was higher than the cut-off value of each index alone(P<0.05).Conclusion There are significant differences in CD
作者
陈红梅
余艳艳
方喆
袁甜
蒋源
CHEN Hong-mei;YU Yan-yan;FANG Zhe;YUAN Tian;JIANG Yuan(Department of Internal Medicine,Hunan Provincial Tuberculosis Control Hospital(Hunan Provincial Chest Hospital))
出处
《公共卫生与预防医学》
2022年第5期77-81,共5页
Journal of Public Health and Preventive Medicine
基金
湖南省卫生健康委科研计划课题项目(C2019036)。
