摘要
目的 基于古今医案云平台和SPSS Modeler软件探析中药灌肠治疗溃疡性结肠炎的用药规律。方法 检索2018年10月31日-2021年10月31日中国知网(CNKI)关于中药灌肠治疗溃疡性结肠炎的临床研究文献,借助古今医案云平台和SPSS Modeler软件,对用药频次、性、味、归经及功效进行统计,运用关联规则、聚类分析和复杂网络分析探析用药规律。结果 筛选出132首中药灌肠方,153味中药,使用频次≥25次的中药有13味,以黄连(77次)、白及(75次)、地榆(62次)为多,药性多寒,药味以苦、甘、涩为主,主归肝、胃、大肠经,主要功效为清热燥湿、清热解毒。关联规则分析显示共现度前三的药对为地榆—白及、黄柏—白及、白头翁—黄连;聚类分析显示有4组聚类方;复杂网络分析显示有白及、地榆、黄柏、黄连、白头翁等24味核心药物。结论 中药灌肠治疗溃疡性结肠炎注重祛肠腑湿热,解火热之毒,兼顾理气调血,补脾柔肝,顾护脾胃,攻邪与扶正并行,处方灵活。常用清热药配伍止血药,善于辨期选药,气、血、湿、瘀同治,组方严谨,切中肯綮,为临床治疗溃疡性结肠炎提供了参考。
Objective Based onancient and modern medical case cloud platform and SPSS Modeler software, the medication rules of traditional Chinese medicine(TCM) enema in the treatment of ulcerative colitis were analyzed.Methods The clinical research literature of TCM enema in the treatment of ulcerative colitis from October2018 to October2021in CNKI was retrieved. With the help of ancient and modern medical case cloud platform and SPSS Modeler software,the frequency, nature, taste, meridian distribution and efficacy of medication were statistically analyzed. The medication rules were analyzed by association rules, cluster analysis and complex network analysis.Results A total of 132TCM enema prescriptions with 153 herbs were screened out. There were 13 herbs used more than or equal to 25 times,most of which were Coptis chinensis(77 times), Bletillae Rhizoma(75 times) and Sanguisorbae Radix(62 times). The medicinal properties were cold, and the herbs were mainly bitter, sweet and astringent. The herbs mainly belonged toliver, stomach and large intestine meridians. The main efficacy was clear heat and dry dampness, clear heat and detoxicating. Association rule analysis showed thattop three drug pairs were Sanguisorbae Radix-Bletillae Rhizoma, Cortex Phellodendri-Bletillae Rhizoma and Pulsatillae Radix-Coptis chinensis. Cluster analysis showed four clusters;complex network analysis showed that there were 24 core drugs, such as Bletillae Rhizoma, Sanguisorbae Radix, Cortex Phellodendri, Coptis chinensis and Pulsatillae Radix.Conclusion TCM enema in the treatment of ulcerative colitis focuses on removing damp-heat in intestines and bowels, relieving the toxic heat of fire, taking into accountregulation of qi and blood, tonifying the spleen and liver, protecting the spleen and stomach, attacking pathogenic factors and supporting the healthy, flexible prescription. Commonly it used asheat-clearing drugs combined with hemostatic drugsand wasgood at phase selection, qi, blood, dampness, blood stasis, rigorous prescription. Also it co
作者
韩海瑞
赵玲玲
林伟
范明明
HAN Hairui;ZHAO Lingling;LIN Wei;FAN Mingming(College of Graduate,Nangang Campus,Heilongjiang Academy of Chinese Medicine,Harbin 150036,China;Department of Spleen and Stomach Diseases,Nangang Campus,Heilongjiang Academy of Chinese Medicine,Harbin 150036,China)
出处
《新疆医科大学学报》
CAS
2022年第8期890-895,共6页
Journal of Xinjiang Medical University
基金
国家卫生健康委“十四五”规划重点课题项目(YYWS2568)。
