摘要
Wnt信号通路可以调控神经干细胞增殖与分化、神经细胞生长与发育,与缺血性脑卒中后的脑缺血/再灌注损伤(cerebral ischemia-reperfusion injury,CIRI)治疗机制有着密切联系。研究表明,一些具有补肾滋肝、益气养阴、活血行气、祛瘀化痰等功效的单味中药及中药复方能激活脑内Wnt信号通路发挥治疗CIRI作用,其中医本质是针对CIRI的肝肾阴虚、气血衰少、血瘀痰毒核心病机进行辨证施治。该文总结了枸杞、山茱萸、姜黄、丹参等单味中药及脑络欣通、丹龙醒脑方、益气活血方、补肾生髓方、黄精丸等中药复方通过调控脑内Wnt信号通路治疗CIRI的研究结果,并分析得出中药补肾生髓、益气填精其现代医学实质与激活Wnt信号通路后促进机体脑血管新生与重塑、刺激脑内特定区域神经干细胞增殖分化有着密切相关性,活血祛瘀、化痰清毒则与激活Wnt信号通路后改善脑部血液供应,发挥抗炎、抗自由基、抗氧化等功能有关。
Wnt signaling pathway can regulate the proliferation and differentiation of neural stem cells,the growth and development of neural cells,which is closely related to the therapeutic mechanism of cerebral ischemia-reperfusion injury(CIRI)after ischemic stroke.Researches have showed that some single Chinese medical herb and Chinese medical herb compounds with the effects of tonifying Shen and nourishing Gan,supplementing Qi and nourishing Yin,promoting Xue and Qi,removing blood stasis and resolving phlegm can activate the Wnt signaling pathway in brains and play the role of treating CIRI,and the essence of the treatment is according to the pathogenesis of CIRI which can be reduced by Yin deficiency of Gan and Shen,Qi and Xue deficiency,blood stasis and phlegm toxin.This paper has summarized the research results of Lycium chinensis,Cornus officinalis,turmeric,Salvia miltiorrhiza and other single Chinese medical herbs and Traditional Chinese Medicine(TCM)compounds such as Naoluoxintong,Danlong Xingnao formula,Yiqi Huoxue Formula,Bushen Shengsui formula and Huangjing pill in the treatment of CIRI,regulating Wnt signaling pathway in brains.We also have analyzed that the essence of modern medicine of tonifying Shen and producing Sui,supplementing Qi and filling Jing in TCM is closely related to promoting cerebral angiogenesis and remodeling and stimulating the proliferation and differentiation of neural stem cells in specific areas of the brain after activating Wnt signaling pathway,and promoting blood circulation and removing blood stasis,resolving phlegm and clearing toxin are related to improving brain blood supply,anti-inflammatory,anti-free radical antioxidation and other functions.
作者
廖可欣
肖爱娇
肖移生
LIAO Ke-xin;XIAO Ai-jiao;XIAO Yi-sheng(College of Traditional Chinese Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2022年第9期1297-1302,共6页
Chinese Pharmacological Bulletin
基金
江西中医药管理局科技计划重点项目(No 2020Z006)
江西省教育厅科技项目(No GJJ190638)
江西省教育厅科学技术研究重点项目(No GJJ201208)
江西省科技厅重点研发计划项目(No 20161BBH80053)。
关键词
WNT信号通路
中药
治疗
脑缺血/再灌注损伤
研究进展
Wnt signaling pathway
traditional Chinese medicine
treatment
cerebral ischemia-reperfusion injury
research progress
