摘要
目的:探讨孕早期炎性因子水平与妊娠期肝内胆汁淤积症(ICP)的相关性。方法:选取安徽医科大学附属安庆医院妇产科2020年1月~2021年6月80例孕妇进行回顾性分析研究,其中孕晚期(28~36周)确诊为ICP的孕妇40例为观察组,对照组为40例孕期胆汁酸正常的孕妇。比较两组产妇孕早期C反应蛋白(CRP)、白细胞计数(WBC)、中性粒细胞计数(NEU)、中性粒细胞百分比(NE)、单核细胞计数(MONO)、总胆汁酸(TBA)、丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)水平,采用受试者工作特征曲线(ROC)和多因素Logistic回归法分析相关指标预测ICP的效力。结果:观察组孕妇孕早期CRP、WBC、NEU、NE、MONO均高于对照组(P<0.05),WBC、NEU、NE、MONO、CRP预测ICP的ROC曲线下面积(AUC)分别为0.792、0.811、0.764、0.740、0.823(P<0.05)。多因素Logistic回归分析显示,NEU(OR=14.124,95%CI:3.284~60.755)、CRP(OR=36.643,95%CI:4.880~275.127)升高均为孕早期ICP发生的危险因素(P<0.05)。结论:孕早期炎性因子的水平与ICP有相关性,但仍需进一步验证。
Objective:To investigate the correlation of the levels of inflammatory factors in the first trimester and incidence of intrahepatic cholestasis of pregnancy(ICP).Methods:Retrospective study was made on 80 maternal cases admitted to the Department of Obstetrics and Gynecology of our hospital between January 2020 and June 2021.Of the 80 women, 40 were diagnosed as ICP at the third trimester(28-36 weeks, observational group),and 40 were of normal bile acid during pregnancy(control group).The two groups were compared concerning the C-reactive protein(CRP),white blood cell count(WBC),neutrophil count(NEU),percentage of neutrophil(NE),monocyte count(MONO),total bile acid(TBA),alaine aminotransferase(ALT),and aspartate aminotransferase(AST)levels in early pregnancy.Receiver operating characteristic ROC curve and binary logistic regression were used to analyze the efficacy of relevant indicators in predicting ICP.Results:Women in the observational group had higher levels of CRP,WBC,NEU,NE% and MONO than those in the control group(all P<0.05).The area under the ROC of WBC,NEU,NE,MONO and CRP for predicting ICP was 0.792,0.811,0.764,0.740 and 0.823,respectively(all P<0.05).Multivariate logistic regression analysis showed that elevated levels of NEU(OR=14.124,95%CI:3.284-60.755) and CRP(OR=36.643,95%CI:4.880-275.127) were risk factors for incidence of ICP(P<0.05).Conclusion:Levels of inflammatory factors in early pregnancy appear responsible for the incidence of ICP,yet further verification remains necessary.
作者
万丽娟
李志芳
李青
WAN Lijuan;LI Zhifang;LI qing(Department of Obstetrics and Gynecology,Anqing Hospital Affiliated to Anhui Medical University,Anqing 246000,China)
出处
《皖南医学院学报》
CAS
2022年第4期357-360,共4页
Journal of Wannan Medical College
基金
安徽省重点研究与开发计划项目(202104j07020035)。
