摘要
目的探讨复发上皮性卵巢癌患者化学治疗前后肠道菌群特征变化。方法本研究为回顾性研究,选取2019年1月至2022年1月湖北文理学院附属医院襄阳市中心医院妇产科收治的86例复发上皮性卵巢癌患者为卵巢癌组,年龄(52.16±10.35)岁,年龄范围为45~70岁。另选取同期在湖北文理学院附属医院襄阳市中心医院进行体检的40名健康女性为健康组,年龄(52.13±10.34)岁,年龄范围为45~70岁。采用荧光定量聚合酶链式反应(PCR)法检测所有研究对象粪便标本中的肠道菌群分布特征。比较两组纳入者化学治疗前后肠道菌群特征的变化。结果健康组变形菌门水平[(9.73±1.15)%]高于卵巢癌组[(7.46±1.26)%],放线菌门水平[(2.63±0.65)%]低于卵巢癌组[(5.47±1.02)%],差异均有统计学意义(P<0.05)。卵巢癌组患者化学治疗后的拟杆菌门、放线菌门水平[(12.29±1.17)%、(4.41±0.74)%]低于化学治疗前[(16.48±2.17)%、(5.47±1.02)%],厚壁菌门、变形菌门水平[(72.83±1.56)%、(18.43±1.42)%]高于化学治疗前[(69.53±3.02)%、(7.46±1.26)%],差异均有统计学意义(P<0.05)。卵巢癌组患者化学治疗前的双歧杆菌属、拟杆菌属、粪梭杆菌属水平[(10.23±1.78)%、(14.32±2.23)%、(15.71±1.04)%]高于化学治疗后[(2.53±0.26)%、(1.72±0.41)%、(3.21±0.16)%],化学治疗前的乳杆菌属、链球菌属、肠志贺菌属水平[(3.42±1.45)%、(1.74±0.08)%、(2.36±1.05)%]低于化学治疗后[(24.06±1.85)%、(8.87±1.46)%、(17.64±1.58)%],差异均有统计学意义(P<0.05)。结论复发上皮性卵巢癌患者的肠道菌群处于失衡状态,使用化学治疗药物治疗后,会抑制肠道正常菌群的生长,进一步加重肠道菌群失调。
Objective To explore the changes of gut microbiota characteristics in patients with recurrent epithelial ovarian cancer before and after chemotherapy.Methods This study was a retrospective study.A total of 86 patients with recurrent epithelial ovarian cancer admitted to the department of Obstetrics and Gynecology from January 2019 to January 2022 were selected as the ovarian cancer group,aged(52.16±10.35)years old,with the age range from 45 to 70 years old.Another 40 healthy women who came to our hospital for physical examination at the same time were selected as the healthy group,age(52.13±10.34)years old,age range from 45 to 70 years old.Fluorescence quantitative polymerase chain reaction(PCR)method was used to detect the distribution characteristics of intestinal flora in fecal samples of all subjects.The changes in the characteristics of intestinal flora before and after chemotherapy were compared between the two groups of research subjects and the observation group.Results Health group door deformation bacteria abundance[(9.73±1.15)%]was higher than that of ovarian cancer group[(7.46±1.26)%],actinomyces door abundance[(2.63±0.65)%]was lower than that in ovarian cancer group[(5.47±1.02)%],the differences were statistically significant(P<0.05).Ovarian cancer group after chemotherapy of bacteroidetes,actinomyces door abundance[(12.29±1.17)%,(4.41±0.74)%]were lower than those before chemotherapy[(16.48±2.17)%,(5.47±1.02)%],the differences were statistically significant(P<0.05).Thick wall fungus door,the door deformation bacteria abundance[(72.83±1.56)%,(18.43±1.42)%]after chemotherapy were higher than those before chemotherapy[(69.53±3.02)%,(7.46±1.26)%],the difference had statistical significance(P<0.05).Ovarian cancer group before chemotherapy of bifidobacterium,bacteroides,clostridium faecalis[(10.23±1.78)%、(14.32±2.23)%、(15.71±1.04)%]were higher than those after chemotherapy[(2.53±0.26)%、(1.72±0.41)%、(3.21±0.16)%],Ovarian cancer group before chemotherapy of lactobacillus,Streptoco
作者
毛小刚
刘韵
Mao Xiaogang;Liu Yun(Department of Obstetrics and Gynecology,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Science,Xiangyang 441021,China)
出处
《中国临床实用医学》
2022年第3期41-44,共4页
China Clinical Practical Medicine
基金
湖北省卫生健康委员会科研项目(WJ2021F063)
襄阳市研究与开发项目(2021ZD03)。
