摘要
目的:探讨子痫前期(PE)患者血清微小RNA-17(miR-17)、miR-25表达的临床意义及对妊娠结局的影响。方法:选取2018年2月至2020年8月我院PE患者74例为PE组,同期选取无妊娠合并症及并发症的正常孕产妇74例为健康组。比较两组一般资料及血清miR-17、miR-25水平,分析血清miR-17、miR-25水平与PE发生的关系及对PE的诊断价值,并分析血清miR-17、miR-25水平与PE患者临床特征和妊娠结局的相关性。结果:PE组舒张压、收缩压、血清miR-17水平高于健康组,分娩孕周、新生儿出生体重、血清miR-25水平低于健康组(P<0.05);Logistic回归分析显示,血清miR-17、miR-25水平均与PE相关(P<0.05);受试者工作特征(ROC)曲线显示,miR-17、miR-25联合诊断PE的AUC最大,为0.918;不同血清miR-17、miR-25水平PE患者舒张压、收缩压、分娩孕周、新生儿出生体重存在明显差异(P<0.05);miR-17、miR-25表达水平与临床特征(舒张压、收缩压)和妊娠结局(分娩孕周、新生儿出生体重)相关(P<0.05)。结论:PE患者血清miR-17、miR-25均病理性表达,且与疾病严重程度和妊娠结局有关。
Objective:To explore the clinical significance of serum microRNA-17(miR-17)and miR-25 expression in patients with preeclampsia(PE)and its influence on pregnancy outcome.Methods:Seventy-four cases of PE patients in our hospital from February 2018 to August 2020 were selected as the PE group,and 74 cases of normal pregnant women without pregnancy comorbidities and complications were selected as the healthy group during the same period.The general data and serum miR-17 and miR-25 levels of the two groups were compared,and the diagnostic value of serum miR-17 and miR-25 levels in relation to the occurrence of PE level on PE was analyzed,and the correlation between serum miR-17 and miR-25 levels and clinical characteristics and pregnancy outcome of PE patients was analyzed.Results:The diastolic blood pressure,systolic blood pressure,and serum miR-17 levels in the PE group were higher than those in the healthy group,and week of delivery,neonatal birth weight,and serum miR-25 levels were lower than in the healthy group(P<0.05);logistic regression analysis showed that serum miR-17 and miR-25 levels were correlated with PE(P<0.05);receiver operating characteristic(ROC)curve shows that the AUC for the combined diagnosis of PE with miR-17 and miR-25 was the largest at 0.918;there were significant differences in diastolic blood pressure,systolic blood pressure,gestational week of delivery,and neonatal birth weight among patients with PE with different serum miR-17 and miR-25 levels(P<0.05);miR-17 and miR-25 expression levels were associated with clinical characteristics(diastolic blood pressure,systolic blood pressure)and pregnancy outcome gestational week of delivery,neonatal birth weight(P<0.05).Conclusion:Serum miR-17 and miR-25 of PE patients are expressed pathologically,and they are related to the severity of the disease and pregnancy outcome.
作者
陈志萍
黄丽珊
吴明秀
陈文婷
CHEN Zhiping;HUANG Lishan;WU Mingxiu(Dongguan Hospital Affiliated to Southern Medical University/Dongguan People's Hospital,Guangdong Dongguan 523000,China)
出处
《河北医学》
CAS
2022年第8期1344-1348,共5页
Hebei Medicine
基金
广东省医学科学技术研究基金项目,(编号:C2019097)。
