摘要
目的:通过观察1例13岁儿童患者应用抗结核药物导致药物性肝损伤(DILI)的治疗过程,探讨临床药师在疾病预防和治疗中的作用。方法:临床药师参与1例儿童应用抗结核药物致DILI的治疗过程,根据抗结核药物治疗药物监测(TDM)结果提出用药建议,调整儿童抗结核药物的治疗方案。结果:临床医师部分采纳药师建议,调整用药方案,患儿病情和肝功能明显改善。结论:TDM是临床药师参与药物治疗的有效技术手段,可保障疾病治疗过程中的用药安全。
Objective:To probe into the role of clinical pharmacists in disease prevention and treatment through the treatment process of a 13-year-old child with drug-induced liver injury(DILI)induced by anti-tuberculous drugs.Methods:The clinical pharmacists participated into the treatment process of a child with DILI induced by anti-tuberculous drugs,put forward suggestions according to the results of therapeutic drug monitoring(TDM)on anti-tuberculous drugs,and adjusted the treatment regimen of anti-tuberculosis drugs in children.Results:The clinicians partly adopted the suggestions by clinical pharmacists and adjusted the medication regimen,the disease conditions and liver function of the children were significantly improved.Conclusion:TDM is an effective technical means for clinical pharmacists to participate into drug treatment,which can ensure the safety of drugs in disease treatment.
作者
鲁虹
史群志
吴戈
刘芳群
Lu Hong;Shi Qunzhi;Wu Ge;Liu Fangqun(Changsha Central Hospital Affiliated to University of South China,Changsha 410004,China)
出处
《儿科药学杂志》
CAS
2022年第8期5-9,共5页
Journal of Pediatric Pharmacy
基金
湖南长沙市2019年第二批重点研发
平台和人才科技计划项目,编号kq1907019。
关键词
药物性肝损伤
抗结核药物
治疗药物监测
drug-induced liver injury
anti-tuberculosis drugs
therapeutic drug monitoring
