摘要
【目的】观察穴位贴敷治疗肺肾气虚证慢性阻塞性肺疾病(COPD)稳定期的临床疗效。【方法】将138例肺肾气虚证慢性阻塞性肺疾病患者随机分为对照组和观察组,每组各69例,对照组给予沙美特罗替卡松粉吸入剂联合常规治疗,观察组在对照组常规治疗的基础上加用穴位贴敷治疗。穴位贴敷药物组成:麻黄、五味子、人参等,取穴:定喘、肺俞、肾俞等。疗程为12周。治疗12周后,评价2组临床疗效,观察2组患者治疗前后肺功能指标第1秒用力呼气量(FEV1)、FEV1占预计值百分比(FEV1%pred)、FEV1与用力肺活量(FVC)比值(FEV1/FVC)、呼气峰值流量(PEF)的变化情况,以及血清肿瘤坏死因子α(TNF-α)、超敏C反应蛋白(Hs-CRP)、白细胞介素6(IL-6)水平的情况。比较2组患者治疗前后圣乔治呼吸问卷(SGRQ)评分与BODE指数评分的变化情况,以及咳嗽、咯痰、喘息、气短症状评分及中医证候积分的情况,并随访治疗期间感冒、COPD急性加重次数、急性加重住院次数的发生情况。【结果】(1)观察组总有效率为92.75%(64/69),对照组为81.16%(56/69)。观察组疗效优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的FEV1、FEV1%pred、FEV1/FVC、PEF水平稍有改善,但差异无统计学意义(P>0.05)。(3)治疗后,2组患者的血清TNF-α、Hs-CRP、IL-6水平明显改善(P<0.05),且观察组在改善血清TNF-α、Hs-CRP、IL-6水平方面明显优于对照组,差异有统计学意义(P<0.05)。(4)治疗后,2组患者的SGRQ症状、活动能力、疾病影响及总分均明显改善(P<0.05),且观察组在改善SGRQ症状、活动能力、疾病影响及总分方面明显优于对照组,差异有统计学意义(P<0.05)。2组患者BODE指数评分,差异无统计学意义(P>0.05)。(5)治疗后,2组患者的咳嗽、咯痰、喘息、气短症状评分及中医证候积分明显改善(P<0.05),且观察组在改善咳嗽、咯痰、喘息、气短症状评分及中医证候�
Objective To observe the clinical efficacy of acupoint application in treating chronic obstructive pulmonary disease(COPD)with lung-qi and kidney-qi deficiency syndrome at stationary stage.Methods A total of 138 COPD patients with lung-qi and kidney-qi deficiency syndrome were randomly divided into the control group and the observation group with 69 patients in each group.The control group was given inhaling salmeterolfluticasone combined with conventional treatment,while the observation group was treated with acupoint application on top of conventional treatment in the control group.The treatment in both groups lasted for 12 weeks.After 12 weeks of treatment,the clinical efficacy of the two groups was evaluated,and the changes in the lung function indexes of first second expiratory volume(FEV1),FEV1 as a percentage of predicted value(FEV1%pred),FEV1 to exertional lung volume(FVC)ratio(FEV1/FVC),peak expiratory flow rate(PEF),and serum tumour necrosis factor-α(TNF-α),hypersensitive c-reactive protein(Hs-CRP)and interleukin-6(IL-6)levels were observed.The changes of St.George Respiratory Questionnaire(SGRQ)score,BODE index score,cough,phlegm,wheeze,shortness of breath symptom score and TCM syndrome scores were compared between two groups before and after treatment,and the occurrence of cold,acute exacerbation times and acute exacerbation hospitalization times during treatment were followed up.Results(1)The total effective rate was 92.75%(64/69)in the observation group and 81.16%(56/69)in the control group.The efficacy of the observation group was superior to that of the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the FEV1,FEV1%pred,FEV1/FVC and PEF levels of the two groups was slightly improved,but the difference was not statistically significant(P>0.05).(3)After treatment,the serum TNF-ɑ,Hs-CRP and IL-6 levels in the two groups was significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving the serum TNF-α,
作者
许志茂
赖慧晶
李家春
李顺芳
詹伟杰
XU Zhi-Mao;LAI Hui-Jing;LI Jia-Chun;LI Shun-Fang;ZHAN Wei-Jie(Foshan Hospital of Traditional Chinese Medicine,Foshan 528000 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2022年第7期1583-1589,共7页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
穴位贴敷
肺肾气虚证
慢性阻塞性肺疾病
稳定期
疗效观察
acupoint application
lung-qi and kidney-qi deficiency syndrome
chronic obstructive pulmonary disease(COPD)
stationary stage
observation of curative effect
