摘要
目的:系统评价穴位贴敷治疗慢性阻塞性肺疾病稳定期的临床有效性以及安全性。方法:全面检索国内外各数据库,检索时间限定在近十年,收集中药穴位贴敷治疗慢性阻塞性肺疾病稳定期的随机对照试验,由2名研究员独立进行文献筛选、信息提取,并进行文献质量评价,应用Revman软件进行Meta分析。结果:共纳入42个RCTs,共计4192名患者,Meta分析结果显示:与西医常规治疗相比,加用穴位贴敷疗法能明显提高有效率[RR=1.23,95%CI(1.19,1.27),P<0.00001],提高FEV1/FVC[MD=4.46,95%CI(3.17,5.76),P<0.00001],改善BODE指数[MD=-0.63,95%CI(-0.87,-0.40),P<0.00001]、SGRQ评分[MD=-6.77,95%CI(-9.81,-3.72),P<0.00001]、CAT评分[MD=-3.33,95%CI(-3.87,-2.79),P<0.00001]及中医证候积分[MD=-3.51,95%CI(-3.96,-3.06),P<0.00001],差异均具有统计学意义,且安全性较好。结论:在COPD稳定期西医常规治疗的基础上加用穴位贴敷疗法能显著改善患者的临床症状,不良反应少,但由于研究存在一定的局限性,仍需高质量的研究进一步提供证据。
Objective:To systematically evaluate the clinical efficacy and safety of acupoint application in the treatment of stable chronic obstructive pulmonary disease.Methods:A comprehensive search of various international and domestic databases was conducted,the search time is limited to recent ten years,collecting traditional Chinese medicine acupoint application in the treatment of chronic obstructive pulmonary disease in stable phase of randomized controlled trials.Literature screening,information extraction and literature quality evaluation were carried out independently by two researchers,and meta-analysis was carried out by Revman software.Results:A total of 42 RCTs with a total of 4192 patients were included.The results of meta-analysis showed that,compared with the routine treatment of western medicine,the addition of acupoint application therapy can significantly in⁃crease the effective rate[RR=1.23,95%CI(1.19,1.27),P<0.00001]and FEV1/FVC[MD=4.46,95%CI(3.17,5.76),P<0.00001],and significantly improved BODE index[MD=−0.63,95%CI(−0.87,−0.40),P<0.00001],SGRQ score[MD=−6.77,95%CI(−9.81,−3.72),P<0.00001],CAT score[MD=−3.33,95%CI(−3.87,−2.79),P<0.00001]and TCM syndrome integral[MD=−3.51,95%CI(−3.96,−3.06),P<0.00001].The differences is statistically significant and the safety is good.Conclusion:On the basis of routine treatment of COPD western medicine,acupoint application therapy can significantly improve the clinical symptoms of patients with less adverse reactions.However,due to the limitations of the research,high⁃quality research is still needed to provide further evidence.
作者
尹雅琴
曾俊睿
沈峰
YIN Ya-qin;ZENG Jun-rui;SHEN Feng(College of Acupuncture and Orthopedics Affiliated to Hubei University of Chinese Medicine,Wuhan 430061,China)
出处
《海南医学院学报》
2023年第21期1655-1663,共9页
Journal of Hainan Medical University
基金
湖北省中医药管理局20232024年度中医药科研项目(ZY2023F138)
国家中医药管理局“全国名中医传承工作室”建设项目[国中医药人教发(2022)5号]。
关键词
穴位贴敷
慢性阻塞性肺疾病
META分析
系统评价
Acupoint sticking therapy
Chronic obstructive pulmonary disease
Meta analysis
Systematic analysis
