摘要
目的观察新生儿呼吸窘迫综合征(NRDS)应用肺泡表面活性物质(PS)辅助机械通气疗法的治疗效果。方法选择2016年2月至2020年9月东莞市茶山医院收治的60例新生儿呼吸窘迫患儿为研究对象,采用随机数表法分为对照组和研究组各30例。对照组患儿在常规治疗基础上进行机械通气治疗,研究组患儿在对照组治疗方案基础上实施PS补充治疗。两组疗程均为一周。比较两组患儿治疗前、治疗24 h后的血气指标[二氧化碳分压(PaCO_(2))、血氧分压(PaO_(2))、动脉氢离子浓度(pH)及氧合指数水平]、呼吸功能[氧浓度分数(FiO_(2))、呼气末期正压(PEEP)、吸气峰压(PIP)、平均气道压(MAP)],同时比较两组患儿用氧时间、住院时间和治疗效果。结果两组患儿治疗前的血气指标、呼吸功能指标比较差异均无统计学意义(P>0.05);治疗后,研究组患儿的PaO_(2)、pH、氧合指数分别为(90.16±8.01)mmHg、7.41±0.16、(280.65±41.38)mmHg,明显高于对照组的(78.63±7.48)mmHg、7.25±0.11、(251.22±36.42)mmHg,差异均具有统计学意义(P<0.05);治疗后,研究组患儿的FiO_(2)、PEEP、PIP、MAP分别为(0.39±0.13)%、(5.28±0.39)cmH_(2)O、(18.27±3.96)cmH_(2)O、(8.04±2.74)cmH_(2)O,明显低于对照组的(0.61±0.20)%、(5.51±0.46)cmH_(2)O、(24.16±4.63)cmH_(2)O、(10.94±3.15)cmH_(2)O,差异均有统计学意义(P<0.05);研究组患儿的用氧时间、住院时间分别为(240.37±70.53)d、(26.63±7.32)d,明显短于对照组的(280.05±81.41)d、(32.42±6.28)d,差异均有统计学意义(P<0.05);研究组患儿的治疗总有效率为96.67%,明显高于对照组的73.33%,差异有统计学意义(P<0.05)。结论NRDS应用PS辅助机械通气法治疗能有效改善患儿呼吸功能及血气指标,缩短康复进程,提高治疗效果。
Objective To analyze the effect of pulmonary surfactant(PS)assisted mechanical ventilation in the treatment of neonatal respiratory distress syndrome(NRDS).Methods Sixty patients of neonatal respiratory distress in Dongguan Chashan Hospital from February 2016 to September 2020 were selected and randomly divided into two groups according to random number table.Patients in the control group were treated with mechanical ventilation,and those in the study group were treated with PS on the basis of the treatment plan of the control group,both for 1 week.Before treatment and at 24 hours after treatment,blood gas index[partial pressure of carbon dioxide(PaCO_(2)),partial pressure of blood oxygen(PaO_(2)),arterial hydrogen ion concentration(pH),and oxygenation index level],respiratory function[oxygen concentration fraction(FiO_(2)),positive end expiratory pressure(PEEP),peak inspiratory pressure(PIP),mean airway pressure(MAP)],duration of oxygen use,length of hospital stay,and curative effect were observed and compared between the two groups.Results There was no significant difference in blood gas index(PaCO_(2),PaO_(2),pH,oxygenation index)and respiratory function(FiO_(2),PEEP,PIP,MAP)between the two groups before treatment(P>0.05).After treatment,PaO_(2),pH,oxygenation index in the study group were(90.16±8.01)mmHg,7.41±0.16,(280.65±41.38)mmHg,respectively,significantly higher than(78.63±7.48)mmHg,7.25±0.11,(251.22±36.42)mmHg in the control group(P<0.05).After treatment,FiO_(2),PEEP,PIP,and MAP in the study group were(0.39±0.13)%,(5.28±0.39)cmH_(2)O,(18.27±3.96)cmH_(2)O,and(8.04±2.74)cmH_(2)O,respectively,significantly lower than(0.61±0.20)%,(5.51±0.46)cmH_(2)O,(24.16±4.63)cmH_(2)O,and(10.94±3.15)cmH_(2)O in the control group(P<0.05).The duration of oxygen use and length of hospital stay in the study group were(240.37±70.53)d and(26.63±7.32)d,respectively,significantly lower than(280.05±81.41)d and(32.42±6.28)d in the control group(P<0.05).The effective rate of the study group was 96.67%,significantly
作者
陆红武
王文静
胡林林
LU Hong-wu;WANG Wen-jing;HU Lin-lin(Department of Pediatrics,Dongguan Chashan Hospital,Dongguan 523380,Guangdong,CHINA)
出处
《海南医学》
CAS
2022年第16期2120-2123,共4页
Hainan Medical Journal
基金
广东省东莞市社会发展科技项目(编号:20211800902892)。
关键词
新生儿
机械通气
呼吸窘迫
肺泡表面活性物质
临床疗效
Neonatal
Mechanical ventilation
Respiratory distress
Pulmonary surfactant
Clinical efficacy
