摘要
微波消融(MWA)是近年来兴起的一种针对实体肿瘤的微创介入治疗技术,具有创伤较小、疗效确切、可重复性等优势.但是,当肿瘤靠近重要脏器或者大血管时,MWA治疗往往不够彻底,由此而导致的残余肿瘤复发是影响MWA远期疗效的桎梏.随着纳米科学在生物医学领域的飞速发展,具有独特理化性质的微波响应型纳米材料为增强MWA疗效、降低瘤周正常组织的热损伤及减少肿瘤复发提供了新的可能性.本文回顾现有微波响应型纳米材料的种类,分析其响应微波并应用于抗肿瘤治疗的作用机制,以期对新型微波响应型纳米材料的构建及其在肿瘤微波治疗领域的进一步临床转化提供系统而全面的参考.
Microwave ablation(MWA)is a minimally-invasive interventional therapeutic technique for solid tumors,which has been emerging in clinical practice in recent years.It has obvious advantages of less trauma,reliable efficacy and repeatability.However,usually MWA can not achieve complete and satisfactory therapeutic efficacy when the tumor is located close to the vital organs or large vessels,resulting in residual tumor recurrence,which is the main cause that affects the long-term efficacy of MWA.With the rapid development of nanoscience in biomedical field,the microwave-responsive nanomaterials that carry unique physical and chemical properties are able to provide new possibilities for enhancing MWA efficacy,reducing the thermal damage to the normal tissues around tumor and decreasing tumor recurrence.This paper aims to make a detailed review about the new available types of microwave-responsive nanomaterials,to analyze the mechanisms of their response to microwave and their therapeutic effect in anti-tumor treatment so as to provide systematic and comprehensive references for the construction of new-type microwave-responsive nanomaterials and their further clinical application in the field of microwave therapy for tumors.
作者
高龙
闫海丽
吴越
王嵘
杜江锋
冯对平
GAO Long;YAN Haili;WU Yue;WANG Rong;DU Jiangfeng;FENG Duiping(Department of Oncological and Vascular Intervention,First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province 030001,China)
出处
《介入放射学杂志》
CSCD
北大核心
2022年第6期623-626,共4页
Journal of Interventional Radiology
基金
山西省重点研发计划项目(201903D321188)
山西省基础研究计划项目(20210302123258)。
关键词
微波响应
纳米材料
肿瘤消融
microwave response
nanomaterial
tumor ablation
