摘要
目的探讨亚临床垂体瘤卒中(SPAA)的临床特点,分析相关垂体瘤的特征。方法回顾性分析潍坊市人民医院2010年1月—2021年4月收治的513例垂体瘤患者的临床资料,详细记录SPAA患者的临床表现、肿瘤体积、肿瘤分泌功能、肿瘤侵袭性等资料。结果SPAA有78例患者,发病率为15.2%(78/513),急性垂体瘤卒中55例,发病率为10.7%(55/513)。最常见临床症状为慢性反复头痛48例(61.5%),其次是缓慢进展的视觉障碍36例(46.2%);出现垂体功能减退28例(35.6%)。发生SPAA的垂体瘤中,大腺瘤58例(74.4%),微腺瘤20例(25.6%);无功能腺瘤51例(65.4%),功能性腺瘤27例(34.6%),其中泌乳素腺瘤最多见为16例(20.5%);侵袭性垂体瘤40例(51.3%)。结论SPAA的临床症状不典型,表现形式复杂,早期临床诊断困难。SPAA的发病率高于急性垂体瘤卒中。发生SPAA的垂体瘤在肿瘤体积、分泌功能、侵袭性等方面具有一定的特征性。
Objective To investigate the clinical manifestations of subclinical pituitary adenoma apoplexy(SPAA)and characteristics of related pituitary adenoma.Methods The clinical data of 513 patients with pituitary adenoma treated in Weifang People s Hospital from January 2010 to April 2021 were analyzed retrospectively.The clinical manifestation,tumor volume,tumor secretory function and invasiveness of the cases were recorded in detail.Results 78 cases were diagnosed with SPAA,with an incidence of 15.2%(78/513).55 cases were diagnosed with acute pituitary apoplexy,with an incidence of 10.7%(55/513).The most common clinical symptoms were chronic recurrent headache in 48 cases(61.5%),followed by slowly progressive visual disturbance in 36 cases(46.2%),and hypopituitarism in 28 cases(35.6%).Among the SPAA cases,58(65.4%)had macroadenoma,20(25.6%)had microadenoma,51 had(65.4%)non-functional pituitary adenoma,and 27(34.6%)had functional adenoma,including 16(20.5%)prolactinoma.40 cases(51.3%)had invasive pituitary adenoma.Conclusions The clinical features of SPAA are atypical and the manifestations are complicated,which make early clinical diagnosis difficult.The incidence of SPAA is higher than that of acute pituitary apoplexy.Pituitary adenoma with SPAA has certain characteristics in terms of tumor volume,secretory function,and invasiveness.
作者
王喆
赵余静
魏广鑫
苗俊杰
解昆明
闫红梅
WANG Zhe;ZHAO Yu-jing;WEI Guang-xin(Department of Neurosurgery,Weifang People s Hospital,Weifang 261041,China)
出处
《临床神经外科杂志》
2022年第4期422-426,共5页
Journal of Clinical Neurosurgery
基金
潍坊市科技发展计划项目(2020YX061)。
关键词
垂体瘤
亚临床卒中
临床表现
特征性
pituitary adenoma
subclinical apoplexy
clinical manifestation
characteristics
