摘要
目的:比较阿立哌唑与奥氮平治疗精神分裂症伴代谢综合征患者的效果。方法:选取2015年6月至2021年1月该院收治的100例精神分裂症伴代谢综合征患者进行前瞻性研究,按随机数字表法分为观察组和对照组各50例。观察组采用阿立哌唑治疗,对照组采用奥氮平治疗,比较两组治疗前后血糖指标[空腹血糖(FBG)、空腹胰岛素(FINS)]水平、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平、阳性和阴性症状量表(PANSS)评分、临床疗效及不良反应发生率。结果:治疗后,观察组FBG和FINS水平与治疗前比较,差异均无统计学意义(P>0.05);对照组FBG和FINS水平均高于治疗前,且观察组FBG和INS水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组TC、TG、LDL-C、HDL-C水平与治疗前比较,差异均无统计学意义(P>0.05);对照组TC、TG、LDL-C水平均高于治疗前,且观察组TC、TG、LDL-C水平均低于对照组,差异有统计学意义(P<0.05);但两组HDL-C水平比较,差异无统计学意义(P>0.05);治疗后,两组阳性症状、阴性症状、一般精神病理评分及PANSS总分均低于治疗前,差异有统计学意义(P<0.05),但组间比较,差异无统计学意义(P>0.05);两组治疗总有效率比较,差异无统计学意义(P>0.05);观察组不良反应发生率为12.00%(6/50),低于对照组的30.00%(15/50),差异有统计学意义(P<0.05)。结论:阿立哌唑与奥氮平均可有效改善精神分裂症伴代谢综合征患者的临床症状,获得良好疗效,但阿立哌唑对糖脂代谢的影响较小,且药物不良反应发生率较低。
Objective:To compare effects of Aripiprazole and Olanzapine in treatment of schizophrenia patients with metabolic syndrome.Methods:100 patients with schizophrenia and metabolic syndrome who were admitted to our hospital from June 2015 to January 2021 was selected for the prospective study and were divided into observation group and control group according to the random number table method,50 cases in each.The observation group was treated with Aripiprazole,while the control group was treated with Olanzapine.The levels of serum blood glucose index[fasting blood glucose(FBG)and fasting insulin(FINS)],the blood lipid index levels[total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],the positive and negative syndrome scale(PANSS)score,the clinical efficacy and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of FBG and FINS in the observation group were not significantly different from those before the treatment(P>0.05).The levels of FBG and FINS in the control group were higher than those before the treatment;the levels of FBG and INS in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of TC,TG,LDL-C and HDL-C in the observation group were not significantly different from those before the treatment(P>0.05).The levels of TC,TG and LDL-C in the control group were higher than those before the treatment;the levels of TC,TG and LDL-C in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in HDL-C levels between the two groups(P>0.05).After the treatment,the positive symptom scale score,the negative symptom scale score,the general psychopathological scale,the other PANSS scores and the total score in the two groups were lower than those
作者
赵妮谊
张海霞
孙秀兰
陈莉萍
陈婷
ZHAO Niyi;ZHANG Haixia;SUN Xiulan;CHEN Liping;CHEN Ting(The Third Mental Health Center of Shanghai Civil Administration,Shanghai 200435,China)
出处
《中国民康医学》
2022年第14期83-85,89,共4页
Medical Journal of Chinese People’s Health
关键词
精神分裂症
代谢综合征
阿立哌唑
奥氮平
糖脂代谢
不良反应
Schizophrenia
Metabolic syndrome
Aripiprazole
Olanzapine
Glucose and lipid metabolism
Adverse reaction
