摘要
目的探讨氨磺必利联合阿立哌唑对长期住院治疗的女性精神分裂症患者骨密度及性激素的影响。方法选取2019-2020年安徽医科大学附属巢湖医院精神科长期住院接受氨磺必利联合阿立哌唑治疗的女性精神分裂症患者121例作为患者组,同期在社区招募年龄、文化程度等与患者组匹配的女性健康体检者50例作为对照组。测定对照组研究对象和患者(治疗前,治疗后6、12个月)垂体泌乳素、雌二醇、孕酮和骨密度水平,并对2组研究对象检测结果进行对比分析。结果患者组患者治疗前垂体泌乳素、雌二醇、孕酮、骨密度水平与对照组比较,差异均无统计学意义(P>0.05);患者组患者治疗后第6、12个月垂体泌乳素水平均明显高于治疗前,雌二醇、孕酮,以及腰椎L_(1)~L_(4)、左侧股骨颈骨密度水平均明显低于治疗前,差异均有统计学意义(P<0.05)。腰椎L_(1)~L_(4)、左侧股骨颈骨密度水平均与泌乳素水平呈明显负相关(R_(1)=-0.624、-0.521,P<0.05)。结论长期住院的女性精神分裂症患者骨密度、雌二醇、孕酮水平均明显降低,垂体泌乳素水平明显升高,骨密度水平与垂体泌乳素水平呈明显负相关。
Objective To explore the effects of amisulpride in combination with aripiprazole on mineral density and sex hormone in female patients with schizophrenia.Methods A total of 121 female schizophrenics hospitalized in Chaohu Hospital of Anhui Medical University from 2019 to 2020 who received amsulpiprazole combined with aripiprazole were selected as the patient group,and 50 healthy female physical examination subjects matched with the patient group in age and education level were recruited as the control group during the same period.The levels of pituitary prolactin,estradiol,progesterone and bone mineral density were measured in the control group and patients(before treatment,6 and 12 months after treatment),and the detection results of the two groups were compared and analyzed.Results Before treatment,there were no significant differences in bone mineral density and sex hormone levels between the patient group and the normal control group(P>0.05).At the 6th and 12th month end of treatment,the level of prolactin in the patient group was significantly higher than that before treatment(P<0.05).At the 6th and 12th month end of treatment,the level of estradiol,progesterone,and bone mineral density were all significantly lower than those before treatment(P<0.05).Pearson correlation analysis showed that the level of bone mineral density was significantly negatively correlated with prolactin levels(R_(1)=-0.624,-0.521,P<0.05).Conclusion The bone mineral density,estradiol,and progesterone level of female schizophrenic patients are significantly decreased,and prolactin level is significantly increased.There is a negative correlation between the bone mineral density and the serum level of prolactin.
作者
焦龙
陈婷婷
JIAO Long;CHEN Tingting(Chaohu Hospital of Anhui Medical University,Psychiatric Department,Chaohu,Anhui 238000,China;The First Affiliated Hospital of Anhui Medical University,Department of Medical Psychology,Hefei,Anhui 230000,China;Hefei Technology College,Medical laboratory technology,Hefei,Anhui 230000,China)
出处
《现代医药卫生》
2021年第20期3457-3459,3464,共4页
Journal of Modern Medicine & Health
基金
安徽省教育厅高校自然科学重点研究项目(KJ2020A0978)
合肥职业技术学院高层次人才科研启动经费资助项目(KYQD201801)
合肥职业技术学院校级科研创新团队重点项目(2021CXTD04)
合肥职业技术学院青年教师教学研究项目(2019JYXM012)。
关键词
精神分裂症
女性
骨密度
性腺甾类激素
阿立哌唑
氨磺必利
Schizophrenia
Femininity
Bone density
Gonadal steroid hormones
Aripiprazole
Amisulpride
