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硬膜外分娩镇痛产妇应用地塞米松降低发热率的研究

Study on the Application of Dexamethasone to Reduce the Fever Rate of Puerperae with Epidural Delivery Analgesia
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摘要 目的评价产妇应用程控硬膜外间歇脉冲镇痛同时给予地塞米松对改善硬膜外相关产妇发热的影响。方法选取2019年10月—2021年9月在莒南县人民医院妇科治疗的366例产妇,采用随机数表法将其分为对照组与地塞米松组,每组183例。所有产妇都给予程控硬膜外间歇脉冲给药,地塞米松组在首剂药物给药完毕后,再通过硬膜外导管给产妇推注地塞米松10 mL。比较对照组与地塞米松组镇痛前、镇痛开始后5 h内及胎儿娩出时产妇体温、产妇的疼痛视觉模拟量表(VAS)评分。结果与对照组比较,地塞米松组产妇在镇痛开始后2、3、4、5 h、娩出时体温显著降低,差异有统计学意义(P<0.05)。两组VAS评分对比,差异无统计学意义(P>0.05)。地塞米松组发热率较对照组显著降低[8.74%(16/183)vs 28.96%(53/183)],差异有统计学意义(χ^(2)=24.450,P<0.001)。结论硬膜外分娩镇痛产妇给予地塞米松后发热率明显降低,不增加不良反应发生率。 Objective To evaluate the effect of programmed epidural intermittent pulse analgesia combined with dexamethasone on improving epidural-related maternal fever.Methods A total of 366 puerperae who were treated in the gynecology department of Junan County People's Hospital from October 2019 to September 2021 were selected.They were divided into control group and dexamethasone group by random number table method,and each group had 183 puerperae.All puerperae were given program-controlled epidural intermittent pulse adminis⁃tration.After the first dose of dexamethasone was administered,10 mL of dexamethasone was injected to the puerpera through an epidural catheter.Visual Analog Scale(VAS)scores of maternal body temperature and pain were compared between the control group and the dexa⁃methasone group before analgesia,within 5 h after analgesia and at fetal delivery.Results Compared with the control group,the maternal body temperature in the dexamethasone group decreased significantly at 2 h,3 h,4 h,and 5 h after the onset of analgesia,and at the time of deliv⁃ery of the fetus,and the difference was statistically significant(P<0.05).However,there was no significant difference in VAS scores between the two groups(P>0.05).The fever rate in the dexamethasone group was significantly lower than that in the control group[8.74%(16/183)vs 28.96%(53/183)],and the difference was statistically significant(χ^(2)=24.450,P<0.001).Conclusion After epidural labor analgesia for puerpe⁃rae given dexamethasone,the fever rate was significantly reduced,and the incidence of adverse reactions did not increase.
作者 彭凡岭 刘付玉 潘翔 张一博 PENG Fanling;LIU Fuyu;PAN Xiang;ZHANG Yibo(Outpatient Operating Room,Junan County People's Hospital,Linyi,Shandong Province,276600 China;Department of Anesthesiology,Linyi People's Hospital,Linyi,Shandong Province,273300 China;Department of Anesthesiology,Pingyi County Hospital of Traditional Chinese Medicine,Linyi,Shandong Province,273300 China)
出处 《世界复合医学》 2022年第6期172-175,共4页 World Journal of Complex Medicine
基金 临沂市2019年科技创新发展计划(201920052)。
关键词 地塞米松 分娩镇痛 产时发热 Dexamethasone Labor analgesia ERMF
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