摘要
目的探讨外周血IL-6、IL-8水平与宫内感染的相关性。方法采用酶联免疫法测定2012年7月至2014年7月本院收治的220例正常产妇、180例产时发热产妇的外周血IL-6、IL-8水平,进行胎盘病理分析,并追踪新生儿结局。结果外周血IL-6、IL-8水平在发热产妇、胎盘病理提示急性炎症及新生儿感染产妇均有所升高,且IL-8水平在新生儿感染产妇中升高最明显。新生儿感染产妇外周血IL-6水平升高,在非感染发热产妇中也表现为升高趋势,两者间差异无显著性(P>0.05)。外周血IL-8水平在新生儿感染产妇中显著升高,其水平与非感染发热产妇间差异具有显著性(P<0.05)。结论外周血IL-8测定是预测宫内感染较为敏感的指标,可以联合其他相关指标,用于临床宫内感染病例的筛选。
Objective To explore the association of IL-6, IL-8 levels and intrauterine infection. Method The level of IL-6 and IL-8 in the plasma of 220 normal pregnant women and 180 fever pregnant women during July, 2012 to July, 2014 were measured by ELISA method. The pathological changes of the placenta were observed and neonatal outcome. Result The serum level of IL-6, IL-8 in both fever cases, placenta acute inflammation cases and neonatal infection cases were higher than afebrile cases. Additionally, the serum IL-8 level of neonatal infection cases is significantly higher than fever cases and placenta acute inflammation cases.While elevated in infectious cases, peripheral blood IL-6 also elevated in uninfectious cases with no difference between them. Peripheral blood IL-8 only elevated in infectious case, so it correlated well with the neonatal intrauterine infection. Conclusion Maternal peripheral blood IL-8 is a more specific index to predict the possible intrauterine infection, it could be used further with other intrauterine infection relating indexes in clinic determination.
作者
李巍
何电
王欣
吴玉梅
LI Wei HE Dian WANG Xin WU Yu-mei(Department of Gynecology Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China Department of Epidemiology and Health Statistics, Public Health Academy, Capital Medical University, Beij＇ing 100069, China Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical UniversitY, Beijing 100026, China)
出处
《中国医刊》
CAS
2017年第1期65-68,共4页
Chinese Journal of Medicine
基金
首都医科大学基础临床合作课题(14JL81)
