摘要
口腔黏膜下纤维性变(oral submucous fibrosis,OSF)是一种胶原沉积疾病,其特征是产生疤痕和组织纤维化,会严重影响患者的口腔功能和生活质量。根据世界卫生组织(WHO)的统计,全球有超过500万OSF患者,恶性转化率为1.5%~15%,因此WHO也将其列入口腔潜在恶性疾患的范畴。现对OSF的临床及基础研究进展进行总结,旨在了解该病发病规律及为临床早期防治提供参考。
Oral submucosal fibrosis(OSF)is a collagen deposition disease characterized by scarring and tissue fibrosis,which can severely affect the oral function and quality of life of patients.According to the World Health Organization(WHO),there are more than 5 million OSF patients worldwide,with malignant transformation rates ranging from 1.5%-15%.Thus WHO has included it in the category of potentially malignant disorders of the oral cavity.The clinical and basic research progress of OSF is reviewed in this paper,with aim to provide a reference for understanding the pathogenesis of the disease and its early clinical prevention and treatment.
作者
唐瞻贵
成雨熹
TANG Zhangui;CHENG Yuxi(Department of Oral and Maxillofacial Surgery,Xiangya Stomatological Hospital,Central South University,Changsha 410078,China)
出处
《口腔医学研究》
CAS
CSCD
北大核心
2022年第8期705-709,共5页
Journal of Oral Science Research
