摘要
目的:研究“肺与大肠相表里”理论下复方苍术方治疗慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)的疗效。方法:临床纳入2018年2月-2021年2月广州中医药大学第一附属医院白云医院收治的80例COPD患者作为研究对象,按随机数字表法将患者分为两组,各40例。其中40例进行常规西医治疗的患者属于对照组,另外40例在对照组基础上加用复方苍术方治疗的患者属于研究组。观察两组患者炎症因子水平、肺功能以及症状积分情况。结果:治疗前两组患者C反应蛋白、肿瘤坏死因子-α、白细胞介素-6以及白细胞介素-8水平的差异无统计学意义(P>0.05);治疗后研究组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6以及白细胞介素-8水平均低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者第一秒用力呼气容积(Forced Expiratory Volume in one Second,FEV_(1))/用力肺活量(Forced Vital Capacity,FVC)、最大通气量(Maximal Voluntary Ventilation,MVV)以及6 min步行距离(6 Minute Walk Distance,6 MWD)水平的差异无统计学意义(P>0.05);治疗后研究组FEV_(1)/FVC以及MVV水平高于对照组,6 MWD长于对照组,差异均有统计学意义(P<0.05)。治疗前两组患者咳嗽、咯痰、喘息、纳呆以及神疲乏力症状积分的差异无统计学意义(P>0.05);治疗后研究组咳嗽、咯痰、喘息、纳呆以及神疲乏力症状积分均小于对照组,差异有统计学意义(P<0.05)。结论:复方苍术方能有效改善COPD患者的肺功能,降低炎症因子水平,改善临床症状,值得临床应用及推广。
Objective:To study the effect of the Fufang Cangzhu prescription(复方苍术方)on chronic obstructive pulmoriary disease(COPD)based on“The lungs and the large intestine are related internally and externally”theory.Methods:A total of 80 cases from February 2018 to February 2021 were selected as research objects.According to random number table method,the included cases were divided into two groups,with 40 cases for each.And 40 cases of taking conventional Western medicine treatment were set as the control group,and the other 40 cases of taking Western medicine plus the Fufang Cangzhu prescription were set as the study group.Results:Before treatment,there were no significantly statistical differences between the groups in C-reactive protein,tumor necrosis factor-α,interleukin(IL)-6 and IL-8 levels(P>0.05).After treatment,the CRP,TNF-α,IL-6 and IL-8 levels in the study group were lower than the control group,with statistically significant differences(P<0.05).Before treatment,there were no significantly statistical difference between the groups in FEV_(1)/FVC,MVV and 6 MWD(P>0.05).After treatment,FEV_(1)/FVC and MVV levels in the study group were higher than the control group,but 6 MWD in the study group was longer than the control group(P<0.05).Before treatment,there were no significantly statistical difference between the groups in cough,expectoration,wheezing,anorexia and fatigue symptom scores(P>0.05).After treatment,the cough,expectoration,wheezing,anorexia and fatigue symptom scores in the study group were lower than the control group,with statistically significant differences(P<0.05).Conclusion:The Fufang Cangzhu prescription can improve the lung function of COPD patient,reduce the inflammatory factors,and relieve clinical symptoms.It is worthy of clinical application and promotion.
出处
《中医临床研究》
2022年第20期78-80,共3页
Clinical Journal Of Chinese Medicine
关键词
复方苍术方
慢性阻塞性肺疾病
肺与大肠相表里
The Fufang Cangzhu prescription
Chronic obstructive pulmonary disease
The lungs and large intestine are related internally and externally
